@article{49850b97510140c9a4a22c47396503eb,
title = "The marmoset as an important primate model for longitudinal studies of neurocognitive aging",
abstract = "Age-related cognitive decline has been extensively studied in humans, but the majority of research designs are cross-sectional and compare across younger and older adults. Longitudinal studies are necessary to capture variability in cognitive aging trajectories but are difficult to carry out in humans and long-lived nonhuman primates. Marmosets are an ideal primate model for neurocognitive aging as their naturally short lifespan facilitates longitudinal designs. In a longitudinal study of marmosets tested on reversal learning starting in middle-age, we found that, on average, the group of marmosets declined in cognitive performance around 8 years of age. However, we found highly variable patterns of cognitive aging trajectories across individuals. Preliminary analyses of brain tissues from this cohort also show highly variable degrees of neuropathology. Future work will tie together behavioral trajectories with brain pathology and provide a window into the factors that predict age-related cognitive decline.",
keywords = "aging, longitudinal study, marmoset, neuropathology, reversal learning",
author = "Rothwell, {Emily S.} and Carmen Freire-Cobo and Merina Varghese and M{\'e}lise Edwards and Janssen, {William G.M.} and Hof, {Patrick R.} and Agn{\`e}s Lacreuse",
note = "Funding Information: Supported by NIH grants R01 AG046266 to AL and F32 AG064925 to ESR. This study adhered to the guidelines for the Ethical Treatment of Nonhuman Primates provided by the American Society of Primatologists. This study was approved by the University of Massachusetts‐Amherst Institutional Animal Care and Use Committee. Research data used for this manuscript are not shared at this time. The authors report no conflicts of interest. Funding Information: Supported by NIH grants R01 AG046266 to AL and F32 AG064925 to ESR. This study adhered to the guidelines for the Ethical Treatment of Nonhuman Primates provided by the American Society of Primatologists. This study was approved by the University of Massachusetts-Amherst Institutional Animal Care and Use Committee. Research data used for this manuscript are not shared at this time. The authors report no conflicts of interest. Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",
year = "2021",
month = nov,
doi = "10.1002/ajp.23271",
language = "English",
volume = "83",
journal = "American Journal of Primatology",
issn = "0275-2565",
publisher = "John Wiley & Sons Inc.",
number = "11",
}