The MAO-A genotype does not modulate resting brain metabolism in adults

Nelly Alia-Klein, Aarti Kriplani, Kith Pradhan, Jim Yeming Ma, Jean Logan, Benjamin Williams, Ian W. Craig, Frank Telang, Dardo Tomasi, Rita Z. Goldstein, Gene Jack Wang, Nora D. Volkow, Joanna S. Fowler

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Variation in the monoamine-oxidase-A (MAO-A) gene has been associated with volumetric changes in corticolimbic regions with differences in their response to relevant emotional tasks. Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalPsychiatry Research - Neuroimaging
Volume164
Issue number1
DOIs
StatePublished - 31 Oct 2008

Keywords

  • Baseline
  • FDG
  • MAO-A

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