The many functions of SMC proteins in chromosome dynamics

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Members of the structural maintenance of chromosomes (SMC) family share a characteristic design and configuration of protein domains that provides the molecular basis for the various functions of this family in chromosome dynamics. SMC proteins have a role in chromosome condensation, sister-chromatid cohesion, DNA repair and recombination, and gene dosage compensation, and they function in somatic and meiotic cells. As more is learned about how their unique design affects their function, a picture of a dynamic and varied protein family is emerging.

Original languageEnglish
Pages (from-to)767-778
Number of pages12
JournalNature Reviews Molecular Cell Biology
Issue number10
StatePublished - 1 Oct 2002


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