The Macroautophagy Machinery in Endo- and Exocytosis

Christian Münz

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Macroautophagy and the autophagy-related gene (Atg) machinery execute during their canonical function cytoplasmic constituent degradation in lysosomes. This canonical function contributes to pathogen restriction and intracellular antigen presentation on major histocompatibility complex (MHC) class II molecules to CD4+ T cells. However, in the recent years, it has become clear that the Atg machinery is also used for other membrane transport functions, including endocytosis and exocytosis. This review describes these non-canonical functions in the context of antigen presentation on MHC class I and II molecules to CD8+ and CD4+ T cells, respectively, and during viral replication. Future studies will need to address how the Atg machinery is modified for these non-canonical functions, gets recruited to the respective sites of membrane modification, and recruits alternative Atg interactors to execute endo- and exocytosis instead of macroautophagy.

Original languageEnglish
Pages (from-to)473-485
Number of pages13
JournalJournal of Molecular Biology
Issue number4
StatePublished - 17 Feb 2017
Externally publishedYes


  • T cells
  • major histocompatibility complex (MHC)
  • virus replication


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