The kinetic significance of cell size. I. Variation of cell cycle parameters with size measured at mitosis

A. Yen, J. Fried, T. Kitahara, Annabel Strife, B. D. Clarkson

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Using a cell line of human lymphoid cells, the kinetic significance of cell size measured at mitosis has been explored using fraction of labelled mitoses data. It was found that smaller cells tend to have progressively longer generation times. The principal mechanism for this generation time dilation is a progressively protracted G 1 duration as cell size decreases. There is a concomitant, but much slighter increase in S phase duration. G 2 duration remains essentially constant irrespective of cell size.

Original languageEnglish
Pages (from-to)295-302
Number of pages8
JournalExperimental Cell Research
Volume95
Issue number2
DOIs
StatePublished - 15 Oct 1975
Externally publishedYes

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