Abstract
Using a cell line of human lymphoid cells, the kinetic significance of cell size measured at mitosis has been explored using fraction of labelled mitoses data. It was found that smaller cells tend to have progressively longer generation times. The principal mechanism for this generation time dilation is a progressively protracted G 1 duration as cell size decreases. There is a concomitant, but much slighter increase in S phase duration. G 2 duration remains essentially constant irrespective of cell size.
Original language | English |
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Pages (from-to) | 295-302 |
Number of pages | 8 |
Journal | Experimental Cell Research |
Volume | 95 |
Issue number | 2 |
DOIs | |
State | Published - 15 Oct 1975 |
Externally published | Yes |