TY - JOUR
T1 - The interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals
AU - Osorio, Ricardo S.
AU - Ayappa, Indu
AU - Mantua, Janna
AU - Gumb, Tyler
AU - Varga, Andrew
AU - Mooney, Anne M.
AU - Burschtin, Omar E.
AU - Taxin, Zachary
AU - During, Emmanuel
AU - Spector, Nicole
AU - Biagioni, Milton
AU - Pirraglia, Elizabeth
AU - Lau, Hiuyan
AU - Zetterberg, Henrik
AU - Blennow, Kaj
AU - Lu, Shou En
AU - Mosconi, Lisa
AU - Glodzik, Lidia
AU - Rapoport, David M.
AU - De Leon, Mony J.
N1 - Funding Information:
The authors would like to thank Dr Pauline McHugh M.D and Schantel Williams for patients' evaluations, John Murray, Catherine Randall, and Ana Rejon for study coordination, Dr Yi Li and Wai Tsui for magnetic resonance imaging review, and Professor Blas Frangione for his valuable comments on the writing of the research summarized here. Supported by grants from: Foundation for Research in Sleep Disorders , 2012 New York University Centers of Excellence Seed Grant , Alzheimer's Association New Investigator Research Grant 11-205479 , New York University Alzheimer's Disease Center Pilot Study Grants , National Institutes of Health : R01 AG13616 , R01 AG022374 , R01 AG12101 , R01 HL118624-01 , and Clinical and Translational Science Institute UL1TR000038 .
PY - 2014/6
Y1 - 2014/6
N2 - Previous studies have suggested a link between sleep disordered breathing (SDB) and dementia risk. In the present study, we analyzed the relationship between SDB severity, cerebrospinal fluid (CSF) Alzheimer's disease-biomarkers, and the ApoE alleles. A total of 95 cognitively normal elderly participants were analyzed for SDB severity, CSF measures of phosphorylated-tau (p-tau), total-tau (t-tau), and amyloid beta 42 (Aβ-42), as well as ApoE allele status. In ApoE3+ subjects, significant differences were found between sleep groups for p-tau (F[df2]= 4.3, p= 0.017), and t-tau (F[df2]= 3.3, p= 0.043). Additionally, among ApoE3+ subjects, the apnea and/or hypopnea with 4% O2-desaturation index was positively correlated with p-tau (r= 0.30, p= 0.023), t-tau (r= 0.31, p= 0.021), and Aβ-42 (r= 0.31, p= 0.021). In ApoE2+ subjects, the apnea and/or hypopnea with 4% O2-desaturation index was correlated with lower levels of CSF Aβ-42 (r=-0.71, p= 0.004), similarly to ApoE4+ subjects where there was also a trend toward lower CSF Aβ-42 levels. Our observations suggest that there is an association between SDB and CSF Alzheimer's disease-biomarkers in cognitively normal elderly individuals. Existing therapies for SDB such as continuous positive airway pressure could delay the onset to mild cognitive impairment or dementia in normal elderly individuals.
AB - Previous studies have suggested a link between sleep disordered breathing (SDB) and dementia risk. In the present study, we analyzed the relationship between SDB severity, cerebrospinal fluid (CSF) Alzheimer's disease-biomarkers, and the ApoE alleles. A total of 95 cognitively normal elderly participants were analyzed for SDB severity, CSF measures of phosphorylated-tau (p-tau), total-tau (t-tau), and amyloid beta 42 (Aβ-42), as well as ApoE allele status. In ApoE3+ subjects, significant differences were found between sleep groups for p-tau (F[df2]= 4.3, p= 0.017), and t-tau (F[df2]= 3.3, p= 0.043). Additionally, among ApoE3+ subjects, the apnea and/or hypopnea with 4% O2-desaturation index was positively correlated with p-tau (r= 0.30, p= 0.023), t-tau (r= 0.31, p= 0.021), and Aβ-42 (r= 0.31, p= 0.021). In ApoE2+ subjects, the apnea and/or hypopnea with 4% O2-desaturation index was correlated with lower levels of CSF Aβ-42 (r=-0.71, p= 0.004), similarly to ApoE4+ subjects where there was also a trend toward lower CSF Aβ-42 levels. Our observations suggest that there is an association between SDB and CSF Alzheimer's disease-biomarkers in cognitively normal elderly individuals. Existing therapies for SDB such as continuous positive airway pressure could delay the onset to mild cognitive impairment or dementia in normal elderly individuals.
KW - Alzheimer's disease
KW - Amyloid beta 42
KW - ApoE
KW - Biomarkers
KW - CSF
KW - Cerebral amyloid angiopathy
KW - Elderly
KW - P-tau
KW - Sleep-disordered breathing
UR - https://www.scopus.com/pages/publications/84903364735
U2 - 10.1016/j.neurobiolaging.2013.12.030
DO - 10.1016/j.neurobiolaging.2013.12.030
M3 - Article
C2 - 24439479
AN - SCOPUS:84903364735
SN - 0197-4580
VL - 35
SP - 1318
EP - 1324
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 6
ER -