The insulin-like growth factor system

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations

Abstract

The insulin-like growth factor (IGF) system in ubiquitous and plays a role in every tissue of the body. It is comprised of ligands, receptors and binding proteins, each with specific functions. While it plays an essential role in embryonic and post-natal development, the IGF system is also important in normal adult physiology. There are now numerous examples of diseases such as diabetes, cancer, and malnutrition in which the IGF system is a major player and, not surprisingly, there are attempts to affect these disorders by manipulating the system.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalExperimental Diabesity Research
Volume4
Issue number4
DOIs
StatePublished - Oct 2003
Externally publishedYes

Keywords

  • Binding proteins
  • Insulin-like growth factors
  • Receptors
  • Signaling pathways

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