The insulin-like growth factor system

Derek Le Roith

doi:10.1155/edr.2003.205

The insulin-like growth factor system

Derek Le Roith

Research output: Contribution to journal › Review article › peer-review

132 Scopus citations

Abstract

The insulin-like growth factor (IGF) system in ubiquitous and plays a role in every tissue of the body. It is comprised of ligands, receptors and binding proteins, each with specific functions. While it plays an essential role in embryonic and post-natal development, the IGF system is also important in normal adult physiology. There are now numerous examples of diseases such as diabetes, cancer, and malnutrition in which the IGF system is a major player and, not surprisingly, there are attempts to affect these disorders by manipulating the system.

Original language	English
Pages (from-to)	205-212
Number of pages	8
Journal	Experimental Diabesity Research
Volume	4
Issue number	4
DOIs	https://doi.org/10.1155/edr.2003.205
State	Published - Oct 2003
Externally published	Yes

Keywords

Binding proteins
Insulin-like growth factors
Receptors
Signaling pathways

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10.1155/edr.2003.205

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The insulin-like growth factor system

Abstract

Keywords

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