The Insular Cortex, Alzheimer Disease Pathology, and Their Effects on Blood Pressure Variability

Juri Kitamura; Michiaki Nagai; Hiroki Ueno; Tomohiko Ohshita; Mai Kikumoto; Megumi Toko; Masaya Kato; Keigo Dote; Hiroshi Yamashita; Kazuomi Kario

doi:10.1097/WAD.0000000000000340

The Insular Cortex, Alzheimer Disease Pathology, and Their Effects on Blood Pressure Variability

Juri Kitamura
, Michiaki Nagai
, Hiroki Ueno
, Tomohiko Ohshita
, Mai Kikumoto
, Megumi Toko
, Masaya Kato
, Keigo Dote
, Hiroshi Yamashita
, Kazuomi Kario

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Recent findings indicate that the human cardiovascular system is regulated by a cortical network comprised of the insular cortex (Ic), anterior cingulate gyrus, and amygdala which is necessary for the regulation of the central autonomic network system. Alzheimer disease (AD) affects the Ic at a preclinical stage. The pathology of AD at the Ic is suggested to predispose the cardiovascular system to detrimental changes such as increased blood pressure variability (BPV). In this review article, we focus on the physiology of the Ic in the relationship between the central autonomic network and BPV. We provide a summary of the published evidence regarding the relationship between Ic damage and exaggerated BPV in the context of AD pathology.

Original language	English
Pages (from-to)	282-291
Number of pages	10
Journal	Alzheimer Disease and Associated Disorders
Volume	34
Issue number	3
DOIs	https://doi.org/10.1097/WAD.0000000000000340
State	Published - 1 Jul 2020
Externally published	Yes

Keywords

Alzheimer disease
blood pressure variability
hypertension
insular cortex

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10.1097/WAD.0000000000000340

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abstract = "Recent findings indicate that the human cardiovascular system is regulated by a cortical network comprised of the insular cortex (Ic), anterior cingulate gyrus, and amygdala which is necessary for the regulation of the central autonomic network system. Alzheimer disease (AD) affects the Ic at a preclinical stage. The pathology of AD at the Ic is suggested to predispose the cardiovascular system to detrimental changes such as increased blood pressure variability (BPV). In this review article, we focus on the physiology of the Ic in the relationship between the central autonomic network and BPV. We provide a summary of the published evidence regarding the relationship between Ic damage and exaggerated BPV in the context of AD pathology.",

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AU - Kitamura, Juri

AU - Nagai, Michiaki

AU - Ueno, Hiroki

AU - Ohshita, Tomohiko

AU - Kikumoto, Mai

AU - Toko, Megumi

AU - Kato, Masaya

AU - Dote, Keigo

AU - Yamashita, Hiroshi

AU - Kario, Kazuomi

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Recent findings indicate that the human cardiovascular system is regulated by a cortical network comprised of the insular cortex (Ic), anterior cingulate gyrus, and amygdala which is necessary for the regulation of the central autonomic network system. Alzheimer disease (AD) affects the Ic at a preclinical stage. The pathology of AD at the Ic is suggested to predispose the cardiovascular system to detrimental changes such as increased blood pressure variability (BPV). In this review article, we focus on the physiology of the Ic in the relationship between the central autonomic network and BPV. We provide a summary of the published evidence regarding the relationship between Ic damage and exaggerated BPV in the context of AD pathology.

AB - Recent findings indicate that the human cardiovascular system is regulated by a cortical network comprised of the insular cortex (Ic), anterior cingulate gyrus, and amygdala which is necessary for the regulation of the central autonomic network system. Alzheimer disease (AD) affects the Ic at a preclinical stage. The pathology of AD at the Ic is suggested to predispose the cardiovascular system to detrimental changes such as increased blood pressure variability (BPV). In this review article, we focus on the physiology of the Ic in the relationship between the central autonomic network and BPV. We provide a summary of the published evidence regarding the relationship between Ic damage and exaggerated BPV in the context of AD pathology.

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KW - blood pressure variability

KW - hypertension

KW - insular cortex

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C2 - 32384285

AN - SCOPUS:85086340539

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EP - 291

JO - Alzheimer Disease and Associated Disorders

JF - Alzheimer Disease and Associated Disorders

IS - 3

ER -

The Insular Cortex, Alzheimer Disease Pathology, and Their Effects on Blood Pressure Variability

Abstract

Keywords

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