The ins and outs of steroid hormone transport across the plasma membrane: Insight from an insect

Ulrich Schweizer; Doreen Braun; Douglas Forrest

doi:10.1210/en.2018-01034

The ins and outs of steroid hormone transport across the plasma membrane: Insight from an insect

Ulrich Schweizer
, Doreen Braun
, Douglas Forrest

Research output: Contribution to journal › Comment/debate

5 Scopus citations

Original language	English
Pages (from-to)	339-340
Number of pages	2
Journal	Endocrinology
Volume	160
Issue number	2
DOIs	https://doi.org/10.1210/en.2018-01034
State	Published - 2019
Externally published	Yes

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10.1210/en.2018-01034

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@article{38110cb4744946e0af151bd0f69aa544,

title = "The ins and outs of steroid hormone transport across the plasma membrane: Insight from an insect",

author = "Ulrich Schweizer and Doreen Braun and Douglas Forrest",

note = "Funding Information: This work was supported in part by the intramural research program at the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health (to D.F.) and Deutsche Forschungsgemeinschaft and intramural funding by Medizinische Fakult{\"a}t of Rheinische Friedrich-Wilhelms-Universit{\"a}t Bonn (to U.S.). Funding Information: An interesting perspective is offered by the thyroid field, which has gone through a similar change of paradigm regarding how thyroid hormone is thought to cross the plasma membrane (3). Thyroid hormones (the active ligand triiodothyronine, T3, and its precursor thyroxine, T4) are hydrophobic and are taken up by many cell types in culture such that import by passive diffusion was often assumed. Nonetheless, biochemical arguments supported carrier-mediated transport, including the fact that T3 and T4 are derivatives of amino acids, a zwitterionic class of molecules that are known to require transporters for transmembrane passage. A breakthrough came from human genetics in 2004 and provided crucial physiological support for the concept of carrier-mediated uptake of T3 and T4. Two reports identified mutations in monocarboxylate transporter 8 (MCT8, SLC16A2), a membrane transporter of T3 and T4, in a syndrome of abnormal thyroid status and psychomotor retardation (Allan-Herndon-Dudley syndrome) (4, 5). Today the concept of carrier-mediated, transmembrane transport of T3 and T4 is supported by",

year = "2019",

doi = "10.1210/en.2018-01034",

language = "English",

volume = "160",

pages = "339--340",

journal = "Endocrinology",

issn = "0013-7227",

publisher = "Endocrine Society",

number = "2",

}

TY - JOUR

T1 - The ins and outs of steroid hormone transport across the plasma membrane

T2 - Insight from an insect

AU - Schweizer, Ulrich

AU - Braun, Doreen

AU - Forrest, Douglas

N1 - Funding Information: This work was supported in part by the intramural research program at the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health (to D.F.) and Deutsche Forschungsgemeinschaft and intramural funding by Medizinische Fakultät of Rheinische Friedrich-Wilhelms-Universität Bonn (to U.S.). Funding Information: An interesting perspective is offered by the thyroid field, which has gone through a similar change of paradigm regarding how thyroid hormone is thought to cross the plasma membrane (3). Thyroid hormones (the active ligand triiodothyronine, T3, and its precursor thyroxine, T4) are hydrophobic and are taken up by many cell types in culture such that import by passive diffusion was often assumed. Nonetheless, biochemical arguments supported carrier-mediated transport, including the fact that T3 and T4 are derivatives of amino acids, a zwitterionic class of molecules that are known to require transporters for transmembrane passage. A breakthrough came from human genetics in 2004 and provided crucial physiological support for the concept of carrier-mediated uptake of T3 and T4. Two reports identified mutations in monocarboxylate transporter 8 (MCT8, SLC16A2), a membrane transporter of T3 and T4, in a syndrome of abnormal thyroid status and psychomotor retardation (Allan-Herndon-Dudley syndrome) (4, 5). Today the concept of carrier-mediated, transmembrane transport of T3 and T4 is supported by

PY - 2019

Y1 - 2019

UR - https://www.scopus.com/pages/publications/85060385440

U2 - 10.1210/en.2018-01034

DO - 10.1210/en.2018-01034

M3 - Comment/debate

C2 - 30576427

AN - SCOPUS:85060385440

SN - 0013-7227

VL - 160

SP - 339

EP - 340

JO - Endocrinology

JF - Endocrinology

IS - 2

ER -