TY - JOUR
T1 - The innate cellular responses to HIV-1 invasion
T2 - Emerging molecules of ancient defense mechanisms
AU - Simm, Malgorzata
PY - 2007/6
Y1 - 2007/6
N2 - Along alternative protective pathways, human cells can synthesize biologically active proteins that interfere with HIV replication, but are not viral antigen specific. HIV is sensitive to several viral inhibitors of cellular origin, such as interferons or interferon-regulated proteins. With the progress of AIDS research it has become evident that the immune cells of some individuals are capable of restricting the virus by secretion of other, yet unidentified factor(s) that can be detected only by their potent antiviral activity. Research efforts to identify this inhibitor of HIV - a "magic bullet" released by our immune cells - have revealed the identity of several novel molecules and added to the knowledge of innate cellular responses to viral invasion.
AB - Along alternative protective pathways, human cells can synthesize biologically active proteins that interfere with HIV replication, but are not viral antigen specific. HIV is sensitive to several viral inhibitors of cellular origin, such as interferons or interferon-regulated proteins. With the progress of AIDS research it has become evident that the immune cells of some individuals are capable of restricting the virus by secretion of other, yet unidentified factor(s) that can be detected only by their potent antiviral activity. Research efforts to identify this inhibitor of HIV - a "magic bullet" released by our immune cells - have revealed the identity of several novel molecules and added to the knowledge of innate cellular responses to viral invasion.
KW - Antiviral factors
KW - CD4 T cells
KW - CD8 T cells
KW - Innate immunity
UR - https://www.scopus.com/pages/publications/34250786654
U2 - 10.1007/s00005-007-0023-9
DO - 10.1007/s00005-007-0023-9
M3 - Review article
C2 - 17557144
AN - SCOPUS:34250786654
SN - 0004-069X
VL - 55
SP - 131
EP - 138
JO - Archivum Immunologiae et Therapiae Experimentalis
JF - Archivum Immunologiae et Therapiae Experimentalis
IS - 3
ER -