The influenza A virus protein PB1-F2: Killing two birds with one stone?

Zsuzsanna T. Varga, Peter Palese

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


ANT3, adenine nucleotide translocator 3; ATF, activating transcription factor; CARD, caspase activation and recruitment domain; IFN, interferon; IKKε, IκB kinase ε; IRF, interferon regulatory transcription factor; ISG, interferon-stimulated gene; JAK, Janus kinase; MAVS, mitochondrial antiviral signaling protein; MDA-5, melanoma differentiation- associated gene-5; NDV, newcastle disease virus; NFκB, nuclear factor κB; NLR, Nod-like receptor; PTPC, permeability-transition pore complex; RIG-I, retinoic acid inducible gene-I; RLH, RIG-I-like RNA helicase receptor; STAT, signal transduction and activator of transcription; TBK1, TANK-binding kinase 1; TNFα, tumor-necrosis factor α; TLR, toll-like receptor; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; TRIF, TIR-domain-containing adapter-inducing interferon-β; VDAC1, voltage-dependent anion channel 1.

Original languageEnglish
Pages (from-to)542-546
Number of pages5
Issue number6
StatePublished - 2011


  • Antiviral signaling
  • Apoptosis
  • Influenza virus
  • Interferon antagonism
  • Mavs
  • PB1-F2
  • PB1-F2 N66S
  • Pathogenicity


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