Abstract
The HIV envelope glycoproteins are critical targets for the host immune system in its fight against the virus. In addition to being renowned for their antigenic and genetic variation, they are among the most heavily glycosylated antigens found on human viruses. This chapter reviews our current knowledge about the role of HIV glycosylation in shaping antibody and T-cell responses. We discuss the importance of N-glycans in modulating HIV envelope glycoprotein recognition by antibodies and the elicitation of antibody responses against these antigens. We also highlight the impact of N-glycans on CD8 and CD4 T-cell recognition of the virus. However, much more research is needed to understand how the numerous glycans on the HIV envelope glycoproteins exert their influence on the host immune system and how the host can mount effective immune responses against envelope antigens shrouded by these glycans. Such information would be crucial in guiding the search for more effective prophylactic and therapeutic modalities required to conquer the HIV epidemic.
| Original language | English |
|---|---|
| Title of host publication | HIV Glycans in Infection and Immunity |
| Publisher | Springer New York |
| Pages | 59-83 |
| Number of pages | 25 |
| Volume | 9781461488729 |
| ISBN (Electronic) | 9781461488729 |
| ISBN (Print) | 1461488710, 9781461488712 |
| DOIs | |
| State | Published - 1 Nov 2014 |
| Externally published | Yes |
Keywords
- Antibodies
- Glycans
- Glycosylation
- HIV
- HIV envelope
- T cells