The influence of HIV envelope glycosylation on adaptive immune response

Catarina E. Hioe, Rajnish Kumar, Shiu Lok Hu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


The HIV envelope glycoproteins are critical targets for the host immune system in its fight against the virus. In addition to being renowned for their antigenic and genetic variation, they are among the most heavily glycosylated antigens found on human viruses. This chapter reviews our current knowledge about the role of HIV glycosylation in shaping antibody and T-cell responses. We discuss the importance of N-glycans in modulating HIV envelope glycoprotein recognition by antibodies and the elicitation of antibody responses against these antigens. We also highlight the impact of N-glycans on CD8 and CD4 T-cell recognition of the virus. However, much more research is needed to understand how the numerous glycans on the HIV envelope glycoproteins exert their influence on the host immune system and how the host can mount effective immune responses against envelope antigens shrouded by these glycans. Such information would be crucial in guiding the search for more effective prophylactic and therapeutic modalities required to conquer the HIV epidemic.

Original languageEnglish
Title of host publicationHIV Glycans in Infection and Immunity
PublisherSpringer New York
Number of pages25
ISBN (Electronic)9781461488729
ISBN (Print)1461488710, 9781461488712
StatePublished - 1 Nov 2014
Externally publishedYes


  • Antibodies
  • Glycans
  • Glycosylation
  • HIV
  • HIV envelope
  • T cells


Dive into the research topics of 'The influence of HIV envelope glycosylation on adaptive immune response'. Together they form a unique fingerprint.

Cite this