Abstract
The potential ability of cytoreductive surgery to increase the effectiveness of chemotherapy (vindesine) was tested utilizing male Wistar Lewis rats transplanted simulataneously with intraperitoneal and flank implants of a spontaneously arising renal adenocarcinoma. Cytoreduction was accomplished in some animals by removing the flank tumor 5-7 weeks following implantation; all animals received vindesine (IP injection of 0.5 mg/kg on two successive weeks). While vindesine reduced tumor growth, in no case did the addition of cytoreductive surgery enhance the effect of chemotherapy. The addition of cytoreductive surgery to marginally effective chemotherapy was found to be ineffective or even detrimental.
| Original language | English |
|---|---|
| Pages (from-to) | 35-38 |
| Number of pages | 4 |
| Journal | Urological Research |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1985 |
| Externally published | Yes |
Keywords
- Chemotherapy
- Cytoreductive surgery
- Rats
- Renal adenocarcinoma