@article{07f5010fdcd54e04abb0a15584e52ddd,
title = "The increased natural killer sensitivity of Epstein-Barr virus (EBV)-superinfected Raji cells is not due to the recognition of serologically determined EBV antigens by the effectors",
abstract = "The NK sensitivity of Raji cells was elevated after superinfection with the P3HR-1 strain of Epstein-Barr virus (EBV). The superinfected cells reacted with EBV antibody-positive sera and this was detectable by ADCC. F(ab′)2 fragments from the antibody-positive sera blocked the ADCC reaction but did not affect attachment of lymphocytes and natural killing. This indicates that the EBV-determined membrane antigens that serve as targets for the reactivity with the sera are not responsible for the increased NK sensitivity.",
author = "Manuel Patarroyo and Eva Klein and George Klein",
note = "Funding Information: Virus. Infectious EBV, derived from the P3HR-1 cell line, was provided by Pfizer Inc. (Maywood, N.J.) under a contract from the Resources Branch, Division of Funding Information: This investigation was supported by Grant I ROl CA25250-02, awarded by the National Cancer Institute, DHEW, and by the Swedish Cancer Society. The P3HR-1 virus was obtained from Pfizer Laboratory, Maywood, New Jersey, under a contract from the Division of Cancer Cause and Prevention, National Cancer Institute (NIH). We thank Drs. W. Henle and G. Henle for the EBV antibody titration of the sera and Mrs. Barbro Ehlin for valuable technical assistance. We are indebted to Dr. Anders Rostn and Raymond Welsh for suggestions and discussions. Manuel Patarroyo is the recipient of a fellowship from the National University of Colombia.",
year = "1982",
month = feb,
doi = "10.1016/0008-8749(82)90207-6",
language = "English",
volume = "67",
pages = "152--159",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",
}