The increase in cyclic-AMP levels elicited by vasoactive intestinal peptide (VIP) in mouse cerebral cortical slices is potentiated by ergot alkaloids

Pierre J. Magistretti; Patrick Hof; Michel Schorderet

doi:10.1016/0197-0186(84)90006-8

The increase in cyclic-AMP levels elicited by vasoactive intestinal peptide (VIP) in mouse cerebral cortical slices is potentiated by ergot alkaloids

Pierre J. Magistretti
, Patrick Hof
, Michel Schorderet

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We have recently observed that noradrenaline potentiates, via the activation of specific α-receptors, the stimulatory effects of vasoactive intestinal peptide on cyclic-AMP levels. We report here that certain ergot derivatives of the ergopeptine class, such as bromocriptine, ergotamine and codergocrine known to interact with alpha-adrenergic receptors, will also potentiate the effects of VIP on cyclic-AMP levels, without increasing directly the levels of the cyclic nucleotide. To our knowledge, these results demonstrate for the first time the existence of an interaction between a neuropeptide and ergot alkaloids within the cerebral cortex.

Original language	English
Pages (from-to)	751-753
Number of pages	3
Journal	Neurochemistry International
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/0197-0186(84)90006-8
State	Published - 1984
Externally published	Yes

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title = "The increase in cyclic-AMP levels elicited by vasoactive intestinal peptide (VIP) in mouse cerebral cortical slices is potentiated by ergot alkaloids",

abstract = "We have recently observed that noradrenaline potentiates, via the activation of specific α-receptors, the stimulatory effects of vasoactive intestinal peptide on cyclic-AMP levels. We report here that certain ergot derivatives of the ergopeptine class, such as bromocriptine, ergotamine and codergocrine known to interact with alpha-adrenergic receptors, will also potentiate the effects of VIP on cyclic-AMP levels, without increasing directly the levels of the cyclic nucleotide. To our knowledge, these results demonstrate for the first time the existence of an interaction between a neuropeptide and ergot alkaloids within the cerebral cortex.",

author = "Magistretti, \{Pierre J.\} and Patrick Hof and Michel Schorderet",

note = "Funding Information: Acknowledgements--This work was supported by grants of Fonds National Sulsse de la Recherche Sclentlfique No 3 423-0 83 to PJM, and No 3 345-0 81 to MS The authors wish to thank Ms Christine Bretton for techmcal assistance, Ms Sylvlanne Bonnet for typing the manuscript and Mr Fred Pdlonel for graphical work",

year = "1984",

doi = "10.1016/0197-0186(84)90006-8",

language = "English",

volume = "6",

pages = "751--753",

journal = "Neurochemistry International",

issn = "0197-0186",

publisher = "Elsevier Ltd.",

number = "6",

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TY - JOUR

T1 - The increase in cyclic-AMP levels elicited by vasoactive intestinal peptide (VIP) in mouse cerebral cortical slices is potentiated by ergot alkaloids

AU - Magistretti, Pierre J.

AU - Hof, Patrick

AU - Schorderet, Michel

N1 - Funding Information: Acknowledgements--This work was supported by grants of Fonds National Sulsse de la Recherche Sclentlfique No 3 423-0 83 to PJM, and No 3 345-0 81 to MS The authors wish to thank Ms Christine Bretton for techmcal assistance, Ms Sylvlanne Bonnet for typing the manuscript and Mr Fred Pdlonel for graphical work

PY - 1984

Y1 - 1984

N2 - We have recently observed that noradrenaline potentiates, via the activation of specific α-receptors, the stimulatory effects of vasoactive intestinal peptide on cyclic-AMP levels. We report here that certain ergot derivatives of the ergopeptine class, such as bromocriptine, ergotamine and codergocrine known to interact with alpha-adrenergic receptors, will also potentiate the effects of VIP on cyclic-AMP levels, without increasing directly the levels of the cyclic nucleotide. To our knowledge, these results demonstrate for the first time the existence of an interaction between a neuropeptide and ergot alkaloids within the cerebral cortex.

AB - We have recently observed that noradrenaline potentiates, via the activation of specific α-receptors, the stimulatory effects of vasoactive intestinal peptide on cyclic-AMP levels. We report here that certain ergot derivatives of the ergopeptine class, such as bromocriptine, ergotamine and codergocrine known to interact with alpha-adrenergic receptors, will also potentiate the effects of VIP on cyclic-AMP levels, without increasing directly the levels of the cyclic nucleotide. To our knowledge, these results demonstrate for the first time the existence of an interaction between a neuropeptide and ergot alkaloids within the cerebral cortex.

UR - https://www.scopus.com/pages/publications/0021714118

U2 - 10.1016/0197-0186(84)90006-8

DO - 10.1016/0197-0186(84)90006-8

M3 - Article

AN - SCOPUS:0021714118

SN - 0197-0186

VL - 6

SP - 751

EP - 753

JO - Neurochemistry International

JF - Neurochemistry International

IS - 6

ER -

The increase in cyclic-AMP levels elicited by vasoactive intestinal peptide (VIP) in mouse cerebral cortical slices is potentiated by ergot alkaloids

Abstract

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