The importance of watching our weights: How the choice of weights for non-independent sib pairs can dramatically alter results

Paul Van Eerdewegh; Josée Dupuis; Susan L. Santangelo; Leigha B. Hayward; Deborah Blacker

doi:10.1002/gepi.1370170763

The importance of watching our weights: How the choice of weights for non-independent sib pairs can dramatically alter results

Paul Van Eerdewegh, Josée Dupuis, Susan L. Santangelo, Leigha B. Hayward, Deborah Blacker

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Handling non-independent sib pairs in families with multiple affected sibs presents a problem in likelihood-based nonparametric linkage analyses. We contrast the more stable partial-likelihood solution in MAPMAKER/SIBS with the extremely variable partial-likelihood approach used in ASPEX, and the potential inflation of lods when the problem is ignored as in BETA.

Original language	English
Pages (from-to)	S373-S378
Journal	Genetic Epidemiology
Volume	17
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/gepi.1370170763
State	Published - 1999
Externally published	Yes

Keywords

Alcoholism
Latent class
Linkage analysis
Partial likelihood

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10.1002/gepi.1370170763

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abstract = "Handling non-independent sib pairs in families with multiple affected sibs presents a problem in likelihood-based nonparametric linkage analyses. We contrast the more stable partial-likelihood solution in MAPMAKER/SIBS with the extremely variable partial-likelihood approach used in ASPEX, and the potential inflation of lods when the problem is ignored as in BETA.",

keywords = "Alcoholism, Latent class, Linkage analysis, Partial likelihood",

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AU - Dupuis, Josée

AU - Santangelo, Susan L.

AU - Hayward, Leigha B.

AU - Blacker, Deborah

PY - 1999

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AB - Handling non-independent sib pairs in families with multiple affected sibs presents a problem in likelihood-based nonparametric linkage analyses. We contrast the more stable partial-likelihood solution in MAPMAKER/SIBS with the extremely variable partial-likelihood approach used in ASPEX, and the potential inflation of lods when the problem is ignored as in BETA.

KW - Alcoholism

KW - Latent class

KW - Linkage analysis

KW - Partial likelihood

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The importance of watching our weights: How the choice of weights for non-independent sib pairs can dramatically alter results

Abstract

Keywords

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