The impact of inflammation on neurocognition and risk for psychosis: a critical review

Sophia Kogan, Luz H. Ospina, Vijay A. Mittal, David Kimhy

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Neurocognitive difficulties are highly prevalent among people with schizophrenia and have been linked to increased inflammation, as well as dysfunction and disability. Poor neurocognitive functioning has also been documented in individuals at clinical high risk for psychosis (CHR) and a burgeoning literature point to alterations in inflammation markers in this population. However, there is limited information regarding the putative link between inflammation and neurocognition in CHR individuals, and the potential role of inflammation in the development of cognitive difficulties and psychosis. As previous reports indicate that early treatment in schizophrenia is associated with better outcomes, there is an urgent need to identify neurobiological mechanisms underlying cognitive deterioration and psychosis in CHR individuals to provide them with care prior to significant cognitive and functional declines. To address this gap in the literature, we review and summarize the relevant literatures on inflammation and neurocognitive dysfunction in schizophrenia and CHR individuals, point to remaining gaps, and suggest directions for future research.

Original languageEnglish
Pages (from-to)793-802
Number of pages10
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number7
StatePublished - 1 Oct 2020


  • Clinical high risk
  • Inflammation
  • Neurocognition
  • Prodrome
  • Psychosis
  • Schizophrenia


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