Persons with chronic spinal cord injury (SCI) are at increased risk for stroke and cardiovascular disease (CVD). Systemic inflammation is commonly observed in persons with SCI and is inversely correlated with mobility. In the general population, light-moderate intensity exercise such as walking reduces risk of stroke, CVD and reduces systemic inflammation. Powered exoskeletons for persons with SCI offer a means to provide physical activity through overground ambulation. It is currently unclear if, and to what extent, exoskeletal-assisted walking (EAW) leads to health benefits associated with walking. A pilot case series was performed to determine if EAW impacts whole blood gene expression in persons with chronic SCI.