TY - JOUR
T1 - The impact of diabetes mellitus on medical complication and mortality rates among inpatients with bullous pemphigoid
AU - Patel, Shreya
AU - Ahsanuddin, Salma
AU - Cadwell, Joshua B.
AU - Lambert, W. Clark
N1 - Publisher Copyright:
© 2021, Royal Academy of Medicine in Ireland.
PY - 2022/8
Y1 - 2022/8
N2 - Background: There is currently limited population-based data on the effect of type 2 diabetes mellitus (T2DM) on bullous pemphigoid (BP) inpatients. Aims: To evaluate the relative comorbidities, medical complications, and mortality rates between BP inpatients with and without T2DM. Methods: All inpatients with a primary BP diagnosis in the National Inpatient Sample from 2003 to 2012 were queried. BP inpatients with or without T2DM were compared to identify disparities in relative comorbidities and medical complications. Comorbidities were established using the Agency for Healthcare Research and Quality standardized values. Medical complications were classified using ICD-9 codes. Results: Of the 1978 BP patients identified, 660 (33.4%) had a concurrent diagnosis of T2DM. These patients had significantly higher rates of concurrent comorbidities, including chronic renal failure, congestive heart failure, iron deficiency anemia, hypertension, obesity, and peripheral vascular disease. On bivariate analysis, T2DM patients also had significantly higher rates of medical complications including acute kidney injury (14.5% vs. 10.1%, p = 0.004) and venous thromboembolism (1.8% vs. 0.5%, p = 0.012). On multivariable-adjusted analysis, the odds of venous thromboembolism (OR = 3.01, p = 0.027) remained increased. Inpatient mortality did not differ between the groups. Conclusions: Our findings suggest that BP inpatients with T2DM have a greater medical comorbidity and complication burden. However, inpatient mortality was not increased.
AB - Background: There is currently limited population-based data on the effect of type 2 diabetes mellitus (T2DM) on bullous pemphigoid (BP) inpatients. Aims: To evaluate the relative comorbidities, medical complications, and mortality rates between BP inpatients with and without T2DM. Methods: All inpatients with a primary BP diagnosis in the National Inpatient Sample from 2003 to 2012 were queried. BP inpatients with or without T2DM were compared to identify disparities in relative comorbidities and medical complications. Comorbidities were established using the Agency for Healthcare Research and Quality standardized values. Medical complications were classified using ICD-9 codes. Results: Of the 1978 BP patients identified, 660 (33.4%) had a concurrent diagnosis of T2DM. These patients had significantly higher rates of concurrent comorbidities, including chronic renal failure, congestive heart failure, iron deficiency anemia, hypertension, obesity, and peripheral vascular disease. On bivariate analysis, T2DM patients also had significantly higher rates of medical complications including acute kidney injury (14.5% vs. 10.1%, p = 0.004) and venous thromboembolism (1.8% vs. 0.5%, p = 0.012). On multivariable-adjusted analysis, the odds of venous thromboembolism (OR = 3.01, p = 0.027) remained increased. Inpatient mortality did not differ between the groups. Conclusions: Our findings suggest that BP inpatients with T2DM have a greater medical comorbidity and complication burden. However, inpatient mortality was not increased.
KW - Bullous pemphigoid
KW - Complications
KW - Diabetes
KW - Inpatient
KW - Mortality
KW - National Inpatient Sample
UR - http://www.scopus.com/inward/record.url?scp=85112587546&partnerID=8YFLogxK
U2 - 10.1007/s11845-021-02726-9
DO - 10.1007/s11845-021-02726-9
M3 - Article
AN - SCOPUS:85112587546
SN - 0021-1265
VL - 191
SP - 1669
EP - 1675
JO - Irish Journal of Medical Science
JF - Irish Journal of Medical Science
IS - 4
ER -