The immunology and immunopathology of COVID-19

Miriam Merad; Catherine A. Blish; Federica Sallusto; Akiko Iwasaki

doi:10.1126/science.abm8108

The immunology and immunopathology of COVID-19

Miriam Merad, Catherine A. Blish, Federica Sallusto, Akiko Iwasaki

Marc and Jennifer Lipschultz Precision Immunology Institute

Research output: Contribution to journal › Review article › peer-review

466 Scopus citations

Abstract

Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify the drivers of severe and fatal COVID-19, and understand what leads to the prolongation of symptoms after disease resolution. We review the results of almost 2 years of COVID-19 immunology research and discuss definitive findings and remaining questions regarding our understanding of COVID-19 pathophysiology. We discuss emerging understanding of differences in immune responses seen in those with and without Long Covid syndrome, also known as post-acute sequelae of SARS-CoV-2. We hope that the knowledge gained from this COVID-19 research will be applied in studies of inflammatory processes involved in critical and chronic illnesses, which remain a major unmet need.

Original language	English
Pages (from-to)	1122-1127
Number of pages	6
Journal	Science
Volume	375
Issue number	6585
DOIs	https://doi.org/10.1126/science.abm8108
State	Published - 11 Mar 2022

Access to Document

10.1126/science.abm8108

Cite this

@article{c72d798b51d54d06953bc62cb2345eb5,

title = "The immunology and immunopathology of COVID-19",

abstract = "Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify the drivers of severe and fatal COVID-19, and understand what leads to the prolongation of symptoms after disease resolution. We review the results of almost 2 years of COVID-19 immunology research and discuss definitive findings and remaining questions regarding our understanding of COVID-19 pathophysiology. We discuss emerging understanding of differences in immune responses seen in those with and without Long Covid syndrome, also known as post-acute sequelae of SARS-CoV-2. We hope that the knowledge gained from this COVID-19 research will be applied in studies of inflammatory processes involved in critical and chronic illnesses, which remain a major unmet need.",

author = "Miriam Merad and Blish, {Catherine A.} and Federica Sallusto and Akiko Iwasaki",

year = "2022",

month = mar,

day = "11",

doi = "10.1126/science.abm8108",

language = "English",

volume = "375",

pages = "1122--1127",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6585",

}

TY - JOUR

T1 - The immunology and immunopathology of COVID-19

AU - Merad, Miriam

AU - Blish, Catherine A.

AU - Sallusto, Federica

AU - Iwasaki, Akiko

PY - 2022/3/11

Y1 - 2022/3/11

N2 - Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify the drivers of severe and fatal COVID-19, and understand what leads to the prolongation of symptoms after disease resolution. We review the results of almost 2 years of COVID-19 immunology research and discuss definitive findings and remaining questions regarding our understanding of COVID-19 pathophysiology. We discuss emerging understanding of differences in immune responses seen in those with and without Long Covid syndrome, also known as post-acute sequelae of SARS-CoV-2. We hope that the knowledge gained from this COVID-19 research will be applied in studies of inflammatory processes involved in critical and chronic illnesses, which remain a major unmet need.

AB - Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify the drivers of severe and fatal COVID-19, and understand what leads to the prolongation of symptoms after disease resolution. We review the results of almost 2 years of COVID-19 immunology research and discuss definitive findings and remaining questions regarding our understanding of COVID-19 pathophysiology. We discuss emerging understanding of differences in immune responses seen in those with and without Long Covid syndrome, also known as post-acute sequelae of SARS-CoV-2. We hope that the knowledge gained from this COVID-19 research will be applied in studies of inflammatory processes involved in critical and chronic illnesses, which remain a major unmet need.

UR - http://www.scopus.com/inward/record.url?scp=85126423644&partnerID=8YFLogxK

U2 - 10.1126/science.abm8108

DO - 10.1126/science.abm8108

M3 - Review article

C2 - 35271343

AN - SCOPUS:85126423644

SN - 0036-8075

VL - 375

SP - 1122

EP - 1127

JO - Science

JF - Science

IS - 6585

ER -

The immunology and immunopathology of COVID-19

Abstract

Access to Document

Fingerprint

Cite this