The human vaccines project: A roadmap for cancer vaccine development

Pedro Romero; Jacques Banchereau; Nina Bhardwaj; Mark Cockett; Mary L. Disis; Glenn Dranoff; Eli Gilboa; Scott A. Hammond; Robert Hershberg; Alan J. Korman; Pia Kvistborg; Cornelis Melief; Ira Mellman; A. Karolina Palucka; Irina Redchenko; Harlan Robins; Federica Sallusto; Theodore Schenkelberg; Stephen Schoenberger; Jeffrey Sosman; Özlem Türeci; BenoÎt Van Den Eynde; Wayne Koff; George Couko

doi:10.1126/scitranslmed.aaf0685

The human vaccines project: A roadmap for cancer vaccine development

Pedro Romero, Jacques Banchereau, Nina Bhardwaj, Mark Cockett, Mary L. Disis, Glenn Dranoff, Eli Gilboa, Scott A. Hammond, Robert Hershberg, Alan J. Korman, Pia Kvistborg, Cornelis Melief, Ira Mellman, A. Karolina Palucka, Irina Redchenko, Harlan Robins, Federica Sallusto, Theodore Schenkelberg, Stephen Schoenberger, Jeffrey SosmanÖzlem Türeci, BenoÎt Van Den Eynde, Wayne Koff, George Couko

Research output: Contribution to journal › Review article › peer-review

154 Scopus citations

Abstract

Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited bymost vaccines tested, but their clinical efficacy remainsmodest.We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.

Original language	English
Article number	334ps9
Journal	Science Translational Medicine
Volume	8
Issue number	334
DOIs	https://doi.org/10.1126/scitranslmed.aaf0685
State	Published - 13 Apr 2016

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Romero, P., Banchereau, J., Bhardwaj, N., Cockett, M., Disis, M. L., Dranoff, G., Gilboa, E., Hammond, S. A., Hershberg, R., Korman, A. J., Kvistborg, P., Melief, C., Mellman, I., Palucka, A. K., Redchenko, I., Robins, H., Sallusto, F., Schenkelberg, T., Schoenberger, S., ... Couko, G. (2016). The human vaccines project: A roadmap for cancer vaccine development. Science Translational Medicine, 8(334), Article 334ps9. https://doi.org/10.1126/scitranslmed.aaf0685

@article{343e41f3cac54d838344d4f321a56121,

title = "The human vaccines project: A roadmap for cancer vaccine development",

abstract = "Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited bymost vaccines tested, but their clinical efficacy remainsmodest.We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.",

author = "Pedro Romero and Jacques Banchereau and Nina Bhardwaj and Mark Cockett and Disis, {Mary L.} and Glenn Dranoff and Eli Gilboa and Hammond, {Scott A.} and Robert Hershberg and Korman, {Alan J.} and Pia Kvistborg and Cornelis Melief and Ira Mellman and Palucka, {A. Karolina} and Irina Redchenko and Harlan Robins and Federica Sallusto and Theodore Schenkelberg and Stephen Schoenberger and Jeffrey Sosman and {\"O}zlem T{\"u}reci and {Van Den Eynde}, Beno{\^I}t and Wayne Koff and George Couko",

note = "Funding Information: This work was supported by the Robert Wood Johnson Foundation and Glaxo Smith Kline.",

year = "2016",

month = apr,

day = "13",

doi = "10.1126/scitranslmed.aaf0685",

language = "English",

volume = "8",

journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

number = "334",

}

Romero, P, Banchereau, J, Bhardwaj, N, Cockett, M, Disis, ML, Dranoff, G, Gilboa, E, Hammond, SA, Hershberg, R, Korman, AJ, Kvistborg, P, Melief, C, Mellman, I, Palucka, AK, Redchenko, I, Robins, H, Sallusto, F, Schenkelberg, T, Schoenberger, S, Sosman, J, Türeci, Ö, Van Den Eynde, B, Koff, W & Couko, G 2016, 'The human vaccines project: A roadmap for cancer vaccine development', Science Translational Medicine, vol. 8, no. 334, 334ps9. https://doi.org/10.1126/scitranslmed.aaf0685

TY - JOUR

T1 - The human vaccines project

T2 - A roadmap for cancer vaccine development

AU - Romero, Pedro

AU - Banchereau, Jacques

AU - Bhardwaj, Nina

AU - Cockett, Mark

AU - Disis, Mary L.

AU - Dranoff, Glenn

AU - Gilboa, Eli

AU - Hammond, Scott A.

AU - Hershberg, Robert

AU - Korman, Alan J.

AU - Kvistborg, Pia

AU - Melief, Cornelis

AU - Mellman, Ira

AU - Palucka, A. Karolina

AU - Redchenko, Irina

AU - Robins, Harlan

AU - Sallusto, Federica

AU - Schenkelberg, Theodore

AU - Schoenberger, Stephen

AU - Sosman, Jeffrey

AU - Türeci, Özlem

AU - Van Den Eynde, BenoÎt

AU - Koff, Wayne

AU - Couko, George

N1 - Funding Information: This work was supported by the Robert Wood Johnson Foundation and Glaxo Smith Kline.

PY - 2016/4/13

Y1 - 2016/4/13

N2 - Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited bymost vaccines tested, but their clinical efficacy remainsmodest.We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.

AB - Cancer vaccine development has been vigorously pursued for 40 years. Immunity to tumor antigens can be elicited bymost vaccines tested, but their clinical efficacy remainsmodest.We argue that a concerted international effort is necessary to understand the human antitumor immune response and achieve clinically effective cancer vaccines.

UR - http://www.scopus.com/inward/record.url?scp=84963801069&partnerID=8YFLogxK

U2 - 10.1126/scitranslmed.aaf0685

DO - 10.1126/scitranslmed.aaf0685

M3 - Review article

C2 - 27075624

AN - SCOPUS:84963801069

SN - 1946-6234

VL - 8

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 334

M1 - 334ps9

ER -

The human vaccines project: A roadmap for cancer vaccine development

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