The human HLA-DR antigens are encoded by multiple β-chain loci

C. K. Hurley, G. Nunez, R. Winchester, O. J. Finn, R. Levy, J. D. Capra

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Monoclonal antibodies have been used to isolate and characterize human HLA-Dr antigens from human B cell lines. Using sequential immunodepletion experiments, several subsets of DR antigens have been identified. Partial amino-terminal amino acid sequencing has identified these subsets as DR molecules with sequences homologous to the murine I-E alloantigens. In addition, sequence data provide evidence for primary structural differences in the DR β-chains of two of the subsets. These results provide primary structural evidence for the presence of multiple DR β-chain loci.

Original languageEnglish
Pages (from-to)2103-2108
Number of pages6
JournalJournal of Immunology
Issue number5
StatePublished - 1982
Externally publishedYes


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