The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules

Margo H. Furman; Neelendu Dey; Domenico Tortorella; Hidde L. Ploegh

doi:10.1128/JVI.76.22.11753-11756.2002

The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules

Margo H. Furman, Neelendu Dey, Domenico Tortorella, Hidde L. Ploegh

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Human cytomegalovirus (HCMV) US10 encodes a glycoprotein that binds to major histocompatibility complex (MHC) class I heavy chains. While expression of US10 delays the normal trafficking of MHC class I molecules out of the endoplasmic reticulum, US10 does not obviously facilitate or inhibit the action of two other HCMV-encoded MHC class I binding proteins, US2 and US11.

Original language	English
Pages (from-to)	11753-11756
Number of pages	4
Journal	Journal of Virology
Volume	76
Issue number	22
DOIs	https://doi.org/10.1128/JVI.76.22.11753-11756.2002
State	Published - Nov 2002
Externally published	Yes

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10.1128/JVI.76.22.11753-11756.2002

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title = "The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules",

abstract = "Human cytomegalovirus (HCMV) US10 encodes a glycoprotein that binds to major histocompatibility complex (MHC) class I heavy chains. While expression of US10 delays the normal trafficking of MHC class I molecules out of the endoplasmic reticulum, US10 does not obviously facilitate or inhibit the action of two other HCMV-encoded MHC class I binding proteins, US2 and US11.",

author = "Furman, {Margo H.} and Neelendu Dey and Domenico Tortorella and Ploegh, {Hidde L.}",

year = "2002",

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AU - Dey, Neelendu

AU - Tortorella, Domenico

AU - Ploegh, Hidde L.

PY - 2002/11

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AB - Human cytomegalovirus (HCMV) US10 encodes a glycoprotein that binds to major histocompatibility complex (MHC) class I heavy chains. While expression of US10 delays the normal trafficking of MHC class I molecules out of the endoplasmic reticulum, US10 does not obviously facilitate or inhibit the action of two other HCMV-encoded MHC class I binding proteins, US2 and US11.

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DO - 10.1128/JVI.76.22.11753-11756.2002

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The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules

Abstract

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