The human brain in a dish: The promise of iPSC-derived neurons

Ricardo Dolmetsch; Daniel H. Geschwind

doi:10.1016/j.cell.2011.05.034

The human brain in a dish: The promise of iPSC-derived neurons

Ricardo Dolmetsch
, Daniel H. Geschwind

Research output: Contribution to journal › Short survey › peer-review

277 Scopus citations

Abstract

Induced pluripotent stem cell-derived neurons from patients promise to fill an important niche between studies in humans and model organisms in deciphering mechanisms and identifying therapeutic avenues for neurologic and psychiatric diseases. Recent work begins to tap this potential and also highlights challenges that must be overcome to be fully realized.

Original language	English
Pages (from-to)	831-834
Number of pages	4
Journal	Cell
Volume	145
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2011.05.034
State	Published - 10 Jun 2011
Externally published	Yes

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title = "The human brain in a dish: The promise of iPSC-derived neurons",

abstract = "Induced pluripotent stem cell-derived neurons from patients promise to fill an important niche between studies in humans and model organisms in deciphering mechanisms and identifying therapeutic avenues for neurologic and psychiatric diseases. Recent work begins to tap this potential and also highlights challenges that must be overcome to be fully realized.",

author = "Ricardo Dolmetsch and Geschwind, \{Daniel H.\}",

note = "Funding Information: The authors acknowledge Giovanni Coppola for critical discussions and help with the figure and Lauren Kawaguchi and Elizabeth Nigh for editorial assistance. The authors also acknowledge support for their research from the NIH (D.H.G. and R.D.), NIA (D.H.G.), NIGMS (R.D.), Autism Speaks (D.H.G), and the Simons Foundation (D.H.G. and R.D.).",

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AB - Induced pluripotent stem cell-derived neurons from patients promise to fill an important niche between studies in humans and model organisms in deciphering mechanisms and identifying therapeutic avenues for neurologic and psychiatric diseases. Recent work begins to tap this potential and also highlights challenges that must be overcome to be fully realized.

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EP - 834

JO - Cell

JF - Cell

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The human brain in a dish: The promise of iPSC-derived neurons

Abstract

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