The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

48 Scopus citations

Abstract

The Hippo Pathway is a master regulatory network that regulates proliferation, cell growth, stemness, differentiation, and cell death. Coordination of these processes by the Hippo Pathway throughout development and in mature organisms in response to diverse external and internal cues plays a role in morphogenesis, in controlling organ size, and in maintaining organ homeostasis. Given the importance of these processes, the Hippo Pathway also plays an important role in organismal health and has been implicated in a variety of diseases including eye disease, cardiovascular disease, neurodegeneration, and cancer. This review will focus on Drosophila reports that identified the core components of the Hippo Pathway revealing specific downstream biological outputs of this complicated network. A brief description of mammalian reports will complement review of the Drosophila studies. This review will also survey upstream regulation of the core components with a focus on feedback mechanisms.

Original languageEnglish
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages181-228
Number of pages48
DOIs
StatePublished - 2017

Publication series

NameCurrent Topics in Developmental Biology
Volume123
ISSN (Print)0070-2153

Keywords

  • Hippo
  • Lats1/2
  • MST1/2
  • Mats
  • Oncogenes
  • Organ homeostasis
  • Sav
  • TAZ
  • Tumor suppressors
  • Warts
  • YAP
  • Yorkie

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