The gut microbial community in metabolic syndrome patients is modified by diet

Carmen Haro, Sonia Garcia-Carpintero, Juan F. Alcala-Diaz, Francisco Gomez-Delgado, Javier Delgado-Lista, Pablo Perez-Martinez, Oriol A. Rangel Zuñiga, Gracia M. Quintana-Navarro, Blanca B. Landa, Jose C. Clemente, Jose Lopez-Miranda, Antonio Camargo, Francisco Perez-Jimenez

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

Intestinal microbiota changes may be involved in the development of metabolic syndrome (MetS), which is a multicomponent disorder frequently associated with obesity. The aim of this study was to test the effect of consuming two healthy diets: a Mediterranean diet and a low-fat high-carbohydrate diet, for 2. years in the gut microbiota of MetS patients and those in the control group. We analyzed the differences in the bacterial community structure between the groups after 2. years of dietary intervention (Mediterranean or low-fat diet) through quantitative polymerase chain reaction using primers, targeting specific bacterial taxa. We observed, at basal time, that the abundance of Bacteroides, Eubacterium and Lactobacillus genera is lower in the control group than in MetS patients, while Bacteroides fragilis group, Parabacteroides distasonis, Bacteroides thetaiotaomicron, Faecalibacterium prausnitzii, Fusobacterium nucleatum, Bifidobacterium longum, Bifidobacterium adolescentis, Ruminococcus flavefaciens subgroup and Eubacterium rectale are depleted in MetS patients (all P values <.05). Additionally, we found that long-term consumption of Mediterranean diet partially restores the population of P. distasonis, B. thetaiotaomicron, F. prausnitzii, B. adolescentis and B. longum in MetS patients (all P values <.05). Our results suggest that the Mediterranean diet could be a useful tool to restore potentially beneficial members of the gut microbiota, although the stability of these changes over time still remains to be assessed.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalJournal of Nutritional Biochemistry
Volume27
DOIs
StatePublished - 1 Jan 2016

Keywords

  • Cardiovascular disease
  • Mediterranean diet
  • Metabolic syndrome
  • Microbiota
  • Obesity

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