The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Mehdi Bouhaddou; Danish Memon; Bjoern Meyer; Kris M. White; Veronica V. Rezelj; Miguel Correa Marrero; Benjamin J. Polacco; James E. Melnyk; Svenja Ulferts; Robyn M. Kaake; Jyoti Batra; Alicia L. Richards; Erica Stevenson; David E. Gordon; Ajda Rojc; Kirsten Obernier; Jacqueline M. Fabius; Margaret Soucheray; Lisa Miorin; Elena Moreno; Cassandra Koh; Quang Dinh Tran; Alexandra Hardy; Rémy Robinot; Thomas Vallet; Benjamin E. Nilsson-Payant; Claudia Hernandez-Armenta; Alistair Dunham; Sebastian Weigang; Julian Knerr; Maya Modak; Diego Quintero; Yuan Zhou; Aurelien Dugourd; Alberto Valdeolivas; Trupti Patil; Qiongyu Li; Ruth Hüttenhain; Merve Cakir; Monita Muralidharan; Minkyu Kim; Gwendolyn Jang; Beril Tutuncuoglu; Joseph Hiatt; Jeffrey Z. Guo; Jiewei Xu; Sophia Bouhaddou; Christopher J.P. Mathy; Anna Gaulton; Emma J. Manners; Eloy Félix; Ying Shi; Marisa Goff; Jean K. Lim; Timothy McBride; Michael C. O'Neal; Yiming Cai; Jason C.J. Chang; David J. Broadhurst; Saker Klippsten; Emmie De wit; Andrew R. Leach; Tanja Kortemme; Brian Shoichet; Melanie Ott; Julio Saez-Rodriguez; Benjamin R. tenOever; R. Dyche Mullins; Elizabeth R. Fischer; Georg Kochs; Robert Grosse; Adolfo García-Sastre; Marco Vignuzzi; Jeffery R. Johnson; Kevan M. Shokat; Danielle L. Swaney; Pedro Beltrao; Nevan J. Krogan

doi:10.1016/j.cell.2020.06.034

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Mehdi Bouhaddou, Danish Memon, Bjoern Meyer, Kris M. White, Veronica V. Rezelj, Miguel Correa Marrero, Benjamin J. Polacco, James E. Melnyk, Svenja Ulferts, Robyn M. Kaake, Jyoti Batra, Alicia L. Richards, Erica Stevenson, David E. Gordon, Ajda Rojc, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Lisa Miorin, Elena MorenoCassandra Koh, Quang Dinh Tran, Alexandra Hardy, Rémy Robinot, Thomas Vallet, Benjamin E. Nilsson-Payant, Claudia Hernandez-Armenta, Alistair Dunham, Sebastian Weigang, Julian Knerr, Maya Modak, Diego Quintero, Yuan Zhou, Aurelien Dugourd, Alberto Valdeolivas, Trupti Patil, Qiongyu Li, Ruth Hüttenhain, Merve Cakir, Monita Muralidharan, Minkyu Kim, Gwendolyn Jang, Beril Tutuncuoglu, Joseph Hiatt, Jeffrey Z. Guo, Jiewei Xu, Sophia Bouhaddou, Christopher J.P. Mathy, Anna Gaulton, Emma J. Manners, Eloy Félix, Ying Shi, Marisa Goff, Jean K. Lim, Timothy McBride, Michael C. O'Neal, Yiming Cai, Jason C.J. Chang, David J. Broadhurst, Saker Klippsten, Emmie De wit, Andrew R. Leach, Tanja Kortemme, Brian Shoichet, Melanie Ott, Julio Saez-Rodriguez, Benjamin R. tenOever, R. Dyche Mullins, Elizabeth R. Fischer, Georg Kochs, Robert Grosse, Adolfo García-Sastre, Marco Vignuzzi, Jeffery R. Johnson, Kevan M. Shokat, Danielle L. Swaney, Pedro Beltrao, Nevan J. Krogan

Research output: Contribution to journal › Article › peer-review

712 Scopus citations

Abstract

Phosphoproteomics analysis of SARS-CoV-2-infected Vero E6 cells reveals host cellular pathways hijacked by viral infection, leading to the identification of small molecules that target dysregulated pathways and elicit potent antiviral efficacy.

Original language	English
Pages (from-to)	685-712.e19
Journal	Cell
Volume	182
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2020.06.034
State	Published - 6 Aug 2020

Keywords

AXL
CDK
MAPK
PIKFYVE
SARS-CoV-2
antiviral
casein kinase II
mass spectrometry
p38
phosphoproteomics

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10.1016/j.cell.2020.06.034

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Bouhaddou, M., Memon, D., Meyer, B., White, K. M., Rezelj, V. V., Correa Marrero, M., Polacco, B. J., Melnyk, J. E., Ulferts, S., Kaake, R. M., Batra, J., Richards, A. L., Stevenson, E., Gordon, D. E., Rojc, A., Obernier, K., Fabius, J. M., Soucheray, M., Miorin, L., ... Krogan, N. J. (2020). The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell, 182(3), 685-712.e19. https://doi.org/10.1016/j.cell.2020.06.034

@article{1263738a2be040acbc2d7e6f589d209a,

title = "The Global Phosphorylation Landscape of SARS-CoV-2 Infection",

abstract = "Phosphoproteomics analysis of SARS-CoV-2-infected Vero E6 cells reveals host cellular pathways hijacked by viral infection, leading to the identification of small molecules that target dysregulated pathways and elicit potent antiviral efficacy.",

keywords = "AXL, CDK, MAPK, PIKFYVE, SARS-CoV-2, antiviral, casein kinase II, mass spectrometry, p38, phosphoproteomics",

author = "Mehdi Bouhaddou and Danish Memon and Bjoern Meyer and White, {Kris M.} and Rezelj, {Veronica V.} and {Correa Marrero}, Miguel and Polacco, {Benjamin J.} and Melnyk, {James E.} and Svenja Ulferts and Kaake, {Robyn M.} and Jyoti Batra and Richards, {Alicia L.} and Erica Stevenson and Gordon, {David E.} and Ajda Rojc and Kirsten Obernier and Fabius, {Jacqueline M.} and Margaret Soucheray and Lisa Miorin and Elena Moreno and Cassandra Koh and Tran, {Quang Dinh} and Alexandra Hardy and R{\'e}my Robinot and Thomas Vallet and Nilsson-Payant, {Benjamin E.} and Claudia Hernandez-Armenta and Alistair Dunham and Sebastian Weigang and Julian Knerr and Maya Modak and Diego Quintero and Yuan Zhou and Aurelien Dugourd and Alberto Valdeolivas and Trupti Patil and Qiongyu Li and Ruth H{\"u}ttenhain and Merve Cakir and Monita Muralidharan and Minkyu Kim and Gwendolyn Jang and Beril Tutuncuoglu and Joseph Hiatt and Guo, {Jeffrey Z.} and Jiewei Xu and Sophia Bouhaddou and Mathy, {Christopher J.P.} and Anna Gaulton and Manners, {Emma J.} and Eloy F{\'e}lix and Ying Shi and Marisa Goff and Lim, {Jean K.} and Timothy McBride and O'Neal, {Michael C.} and Yiming Cai and Chang, {Jason C.J.} and Broadhurst, {David J.} and Saker Klippsten and {De wit}, Emmie and Leach, {Andrew R.} and Tanja Kortemme and Brian Shoichet and Melanie Ott and Julio Saez-Rodriguez and tenOever, {Benjamin R.} and Mullins, {R. Dyche} and Fischer, {Elizabeth R.} and Georg Kochs and Robert Grosse and Adolfo Garc{\'i}a-Sastre and Marco Vignuzzi and Johnson, {Jeffery R.} and Shokat, {Kevan M.} and Swaney, {Danielle L.} and Pedro Beltrao and Krogan, {Nevan J.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

day = "6",

doi = "10.1016/j.cell.2020.06.034",

language = "English",

volume = "182",

pages = "685--712.e19",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "3",

}

Bouhaddou, M, Memon, D, Meyer, B, White, KM, Rezelj, VV, Correa Marrero, M, Polacco, BJ, Melnyk, JE, Ulferts, S, Kaake, RM, Batra, J, Richards, AL, Stevenson, E, Gordon, DE, Rojc, A, Obernier, K, Fabius, JM, Soucheray, M, Miorin, L, Moreno, E, Koh, C, Tran, QD, Hardy, A, Robinot, R, Vallet, T, Nilsson-Payant, BE, Hernandez-Armenta, C, Dunham, A, Weigang, S, Knerr, J, Modak, M, Quintero, D, Zhou, Y, Dugourd, A, Valdeolivas, A, Patil, T, Li, Q, Hüttenhain, R, Cakir, M, Muralidharan, M, Kim, M, Jang, G, Tutuncuoglu, B, Hiatt, J, Guo, JZ, Xu, J, Bouhaddou, S, Mathy, CJP, Gaulton, A, Manners, EJ, Félix, E, Shi, Y, Goff, M, Lim, JK, McBride, T, O'Neal, MC, Cai, Y, Chang, JCJ, Broadhurst, DJ, Klippsten, S, De wit, E, Leach, AR, Kortemme, T, Shoichet, B, Ott, M, Saez-Rodriguez, J, tenOever, BR, Mullins, RD, Fischer, ER, Kochs, G, Grosse, R, García-Sastre, A, Vignuzzi, M, Johnson, JR, Shokat, KM, Swaney, DL, Beltrao, P & Krogan, NJ 2020, 'The Global Phosphorylation Landscape of SARS-CoV-2 Infection', Cell, vol. 182, no. 3, pp. 685-712.e19. https://doi.org/10.1016/j.cell.2020.06.034

TY - JOUR

T1 - The Global Phosphorylation Landscape of SARS-CoV-2 Infection

AU - Bouhaddou, Mehdi

AU - Memon, Danish

AU - Meyer, Bjoern

AU - White, Kris M.

AU - Rezelj, Veronica V.

AU - Correa Marrero, Miguel

AU - Polacco, Benjamin J.

AU - Melnyk, James E.

AU - Ulferts, Svenja

AU - Kaake, Robyn M.

AU - Batra, Jyoti

AU - Richards, Alicia L.

AU - Stevenson, Erica

AU - Gordon, David E.

AU - Rojc, Ajda

AU - Obernier, Kirsten

AU - Fabius, Jacqueline M.

AU - Soucheray, Margaret

AU - Miorin, Lisa

AU - Moreno, Elena

AU - Koh, Cassandra

AU - Tran, Quang Dinh

AU - Hardy, Alexandra

AU - Robinot, Rémy

AU - Vallet, Thomas

AU - Nilsson-Payant, Benjamin E.

AU - Hernandez-Armenta, Claudia

AU - Dunham, Alistair

AU - Weigang, Sebastian

AU - Knerr, Julian

AU - Modak, Maya

AU - Quintero, Diego

AU - Zhou, Yuan

AU - Dugourd, Aurelien

AU - Valdeolivas, Alberto

AU - Patil, Trupti

AU - Li, Qiongyu

AU - Hüttenhain, Ruth

AU - Cakir, Merve

AU - Muralidharan, Monita

AU - Kim, Minkyu

AU - Jang, Gwendolyn

AU - Tutuncuoglu, Beril

AU - Hiatt, Joseph

AU - Guo, Jeffrey Z.

AU - Xu, Jiewei

AU - Bouhaddou, Sophia

AU - Mathy, Christopher J.P.

AU - Gaulton, Anna

AU - Manners, Emma J.

AU - Félix, Eloy

AU - Shi, Ying

AU - Goff, Marisa

AU - Lim, Jean K.

AU - McBride, Timothy

AU - O'Neal, Michael C.

AU - Cai, Yiming

AU - Chang, Jason C.J.

AU - Broadhurst, David J.

AU - Klippsten, Saker

AU - De wit, Emmie

AU - Leach, Andrew R.

AU - Kortemme, Tanja

AU - Shoichet, Brian

AU - Ott, Melanie

AU - Saez-Rodriguez, Julio

AU - tenOever, Benjamin R.

AU - Mullins, R. Dyche

AU - Fischer, Elizabeth R.

AU - Kochs, Georg

AU - Grosse, Robert

AU - García-Sastre, Adolfo

AU - Vignuzzi, Marco

AU - Johnson, Jeffery R.

AU - Shokat, Kevan M.

AU - Swaney, Danielle L.

AU - Beltrao, Pedro

AU - Krogan, Nevan J.

PY - 2020/8/6

Y1 - 2020/8/6

N2 - Phosphoproteomics analysis of SARS-CoV-2-infected Vero E6 cells reveals host cellular pathways hijacked by viral infection, leading to the identification of small molecules that target dysregulated pathways and elicit potent antiviral efficacy.

AB - Phosphoproteomics analysis of SARS-CoV-2-infected Vero E6 cells reveals host cellular pathways hijacked by viral infection, leading to the identification of small molecules that target dysregulated pathways and elicit potent antiviral efficacy.

KW - AXL

KW - CDK

KW - MAPK

KW - PIKFYVE

KW - SARS-CoV-2

KW - antiviral

KW - casein kinase II

KW - mass spectrometry

KW - p38

KW - phosphoproteomics

UR - http://www.scopus.com/inward/record.url?scp=85087705559&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2020.06.034

DO - 10.1016/j.cell.2020.06.034

M3 - Article

C2 - 32645325

AN - SCOPUS:85087705559

SN - 0092-8674

VL - 182

SP - 685-712.e19

JO - Cell

JF - Cell

IS - 3

ER -

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Abstract

Keywords

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