The genetics of Parkinson's syndromes: a critical review

John Hardy; Patrick Lewis; Tamas Revesz; Andrew Lees; Coro Paisan-Ruiz

doi:10.1016/j.gde.2009.03.008

The genetics of Parkinson's syndromes: a critical review

John Hardy, Patrick Lewis, Tamas Revesz, Andrew Lees, Coro Paisan-Ruiz

Research output: Contribution to journal › Review article › peer-review

182 Scopus citations

Abstract

Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.

Original language	English
Pages (from-to)	254-265
Number of pages	12
Journal	Current Opinion in Genetics and Development
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.gde.2009.03.008
State	Published - Jun 2009
Externally published	Yes

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title = "The genetics of Parkinson's syndromes: a critical review",

abstract = "Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.",

author = "John Hardy and Patrick Lewis and Tamas Revesz and Andrew Lees and Coro Paisan-Ruiz",

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AU - Hardy, John

AU - Lewis, Patrick

AU - Revesz, Tamas

AU - Lees, Andrew

AU - Paisan-Ruiz, Coro

PY - 2009/6

Y1 - 2009/6

N2 - Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.

AB - Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.

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U2 - 10.1016/j.gde.2009.03.008

DO - 10.1016/j.gde.2009.03.008

M3 - Review article

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VL - 19

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EP - 265

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 3

ER -

The genetics of Parkinson's syndromes: a critical review

Abstract

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