The future of diabetes

Mariela Glandt, Zachary Bloomgarden

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Understanding the "future" of diabetes requires an appreciation of its relationship to the epidemic of obesity and inactivity affecting most of the world, as well as a realization that addressing issues with adherence - as defined by lifestyle and by use of appropriate medications - are crucial to future efforts to improve diabetes outcome. We need to ascertain appropriate therapeutic targets for specific groups of individuals with diabetes as we develop novel therapeutic approaches. Among such approaches are novel insulin secretagogues, including agents derived from gut hormones, which may as well have further beneficial effects, inhibitors of counter-regulatory hormones, agents aimed at reducing cellular inflammation, specific adipokines, and peroxisome proliferator-activated receptor modulators. Furthermore, technologies to mimic the action of the pancreas in controlling glycemia are being developed and show promise in the treatment of diabetes.

Original languageEnglish
Title of host publicationPrinciples of Diabetes Mellitus
Subtitle of host publicationThird Edition
PublisherSpringer International Publishing
Pages999-1012
Number of pages14
ISBN (Electronic)9783319187419
ISBN (Print)9783319187402
DOIs
StatePublished - 7 Jul 2017
Externally publishedYes

Keywords

  • Adherence
  • Adipokines
  • Anti-inflammatory agents
  • Diabetes mellitus
  • Insulin secretagogues
  • Insulin sensitizers
  • Lifestyle modification
  • Obesity

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