The functional role of PRC2 in early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) - mechanisms and opportunities

Kathrin M. Bernt; Stephen P. Hunger; Tobias Neff

doi:10.3389/fped.2016.00049

The functional role of PRC2 in early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) - mechanisms and opportunities

Kathrin M. Bernt
, Stephen P. Hunger
, Tobias Neff

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.

Original language	English
Article number	49
Journal	Frontiers in Pediatrics
Volume	4
Issue number	MAY
DOIs	https://doi.org/10.3389/fped.2016.00049
State	Published - 1 May 2016
Externally published	Yes

Keywords

Epigenetics
Hox genes
JAK/STAT signaling pathway
Leukemia
Lymphoid
Polycomb repressive complex

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10.3389/fped.2016.00049

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title = "The functional role of PRC2 in early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) - mechanisms and opportunities",

abstract = "Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.",

keywords = "Epigenetics, Hox genes, JAK/STAT signaling pathway, Leukemia, Lymphoid, Polycomb repressive complex",

author = "Bernt, \{Kathrin M.\} and Hunger, \{Stephen P.\} and Tobias Neff",

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AU - Bernt, Kathrin M.

AU - Hunger, Stephen P.

AU - Neff, Tobias

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.

AB - Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.

KW - Epigenetics

KW - Hox genes

KW - JAK/STAT signaling pathway

KW - Leukemia

KW - Lymphoid

KW - Polycomb repressive complex

UR - https://www.scopus.com/pages/publications/85047035698

U2 - 10.3389/fped.2016.00049

DO - 10.3389/fped.2016.00049

M3 - Review article

AN - SCOPUS:85047035698

SN - 2296-2360

VL - 4

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

IS - MAY

M1 - 49

ER -

The functional role of PRC2 in early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) - mechanisms and opportunities

Abstract

Keywords

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