TY - JOUR
T1 - The fluorescence of thyroid tissue
AU - Pitman, Michael Jay
AU - Rosenthal, Joshua Michael
AU - Savage, Howard E.
AU - Yu, Goupei
AU - McCormick, Steven A.
AU - Katz, Alvin
AU - Alfano, Robert R.
AU - Schantz, Stimson Pryor
N1 - Funding Information:
This study was supported by an American Academy of Otolaryngology Resident Research Grant.
PY - 2004/11
Y1 - 2004/11
N2 - To investigate the fluorescent characteristics of different thyroid tissues. Fresh ex vivo thyroid tissue was surfaced scanned with a fluorescence spectrophotometer. Resultant spectra were evaluated via interpeak ratios. Interpeak ratios of all histologies were found to be significantly different from each other (P < 0.001). The diagnostic sensitivity and specificity of fluorescent spectroscopy was 86% and 91% for thyroid nodule capsule, 78% and 59% for papillary thyroid carcinoma, and 82% and 63% for normal thyroid, respectively. Fluorescent spectroscopy can been used to identify significant differences in the fluorescent characteristics of various thyroid histologies. This study is the first investigation of the fluorescence of thyroid tissue. The diagnostic ability of fluorescent spectrometry may allow it to be used as a localization aid for fine needle aspiration, using optical fiber probes. Further investigations may enhance the sensitivity and specificity of fluorescent spectrometry allowing it to replace or compliment fine needle aspiration. EBM rating: B-3.
AB - To investigate the fluorescent characteristics of different thyroid tissues. Fresh ex vivo thyroid tissue was surfaced scanned with a fluorescence spectrophotometer. Resultant spectra were evaluated via interpeak ratios. Interpeak ratios of all histologies were found to be significantly different from each other (P < 0.001). The diagnostic sensitivity and specificity of fluorescent spectroscopy was 86% and 91% for thyroid nodule capsule, 78% and 59% for papillary thyroid carcinoma, and 82% and 63% for normal thyroid, respectively. Fluorescent spectroscopy can been used to identify significant differences in the fluorescent characteristics of various thyroid histologies. This study is the first investigation of the fluorescence of thyroid tissue. The diagnostic ability of fluorescent spectrometry may allow it to be used as a localization aid for fine needle aspiration, using optical fiber probes. Further investigations may enhance the sensitivity and specificity of fluorescent spectrometry allowing it to replace or compliment fine needle aspiration. EBM rating: B-3.
UR - http://www.scopus.com/inward/record.url?scp=7444230604&partnerID=8YFLogxK
U2 - 10.1016/j.otohns.2004.05.014
DO - 10.1016/j.otohns.2004.05.014
M3 - Article
C2 - 15523437
AN - SCOPUS:7444230604
SN - 0194-5998
VL - 131
SP - 623
EP - 627
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 5
ER -