TY - JOUR
T1 - The first 12 months of COVID-19
T2 - a timeline of immunological insights
AU - Carvalho, Thiago
AU - Krammer, Florian
AU - Iwasaki, Akiko
N1 - Funding Information:
Given that there are more than 30,000 papers on COVID-19 and SARS-CoV-2, the authors apologize to those whose work is not cited. Work in the Iwasaki laboratory is supported by the Howard Hughes Medical Institute, National Institutes of Health, Women’s Health Research at Yale Pilot Project Program, Fast Grant from Emergent Ventures at the Mercatus Center, Mathers Foundation, the Ludwig Family Foundation, and the Beatrice Kleinberg Neuwirth Fund. Work in the Krammer laboratory on SARS-CoV-2 is partially supported by the NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS) contract HHSN272201400008C, Collaborative Influenza Vaccine Innovation Centers (CIVIC) contract 75N93019C00051, and the generous support of the JPB foundation, the Open Philanthropy Project (#2020-215611) and other philanthropic donations. The authors thank Annsea Park for help with illustration and the members of our laboratories for helpful comments.
Publisher Copyright:
© 2021, Springer Nature Limited.
PY - 2021/4
Y1 - 2021/4
N2 - Since the initial reports of a cluster of pneumonia cases of unidentified origin in Wuhan, China, in December 2019, the novel coronavirus that causes this disease — severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) — has spread throughout the world, igniting the twenty-first century’s deadliest pandemic. Over the past 12 months, a dizzying array of information has emerged from numerous laboratories, covering everything from the putative origin of SARS-CoV-2 to the development of numerous candidate vaccines. Many immunologists quickly pivoted from their existing research to focus on coronavirus disease 2019 (COVID-19) and, owing to this unprecedented convergence of efforts on one viral infection, a remarkable body of work has been produced and disseminated, through both preprint servers and peer-reviewed journals. Here, we take readers through the timeline of key discoveries during the first year of the pandemic, which showcases the extraordinary leaps in our understanding of the immune response to SARS-CoV-2 and highlights gaps in our knowledge as well as areas for future investigations.
AB - Since the initial reports of a cluster of pneumonia cases of unidentified origin in Wuhan, China, in December 2019, the novel coronavirus that causes this disease — severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) — has spread throughout the world, igniting the twenty-first century’s deadliest pandemic. Over the past 12 months, a dizzying array of information has emerged from numerous laboratories, covering everything from the putative origin of SARS-CoV-2 to the development of numerous candidate vaccines. Many immunologists quickly pivoted from their existing research to focus on coronavirus disease 2019 (COVID-19) and, owing to this unprecedented convergence of efforts on one viral infection, a remarkable body of work has been produced and disseminated, through both preprint servers and peer-reviewed journals. Here, we take readers through the timeline of key discoveries during the first year of the pandemic, which showcases the extraordinary leaps in our understanding of the immune response to SARS-CoV-2 and highlights gaps in our knowledge as well as areas for future investigations.
UR - http://www.scopus.com/inward/record.url?scp=85102862128&partnerID=8YFLogxK
U2 - 10.1038/s41577-021-00522-1
DO - 10.1038/s41577-021-00522-1
M3 - Review article
C2 - 33723416
AN - SCOPUS:85102862128
SN - 1474-1733
VL - 21
SP - 245
EP - 256
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 4
ER -