The F-actin bundler SWAP-70 promotes tumor metastasis

Chao Yuan Chang, Glen Pearce, Viktoria Betaneli, Tatsiana Kapustsenka, Kamran Hosseini, Elisabeth Fischer-Friedrich, Denis Corbeil, Jana Karbanová, Anna Taubenberger, Björn Dahncke, Martina Rauner, Giulia Furesi, Sven Perner, Fabian Rost, Rolf Jessberger

Research output: Contribution to journalArticlepeer-review

Abstract

Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.

Original languageEnglish
JournalLife Science Alliance
Volume7
Issue number8
DOIs
StatePublished - 1 Aug 2024
Externally publishedYes

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