TY - JOUR
T1 - The F-actin bundler SWAP-70 promotes tumor metastasis
AU - Chang, Chao Yuan
AU - Pearce, Glen
AU - Betaneli, Viktoria
AU - Kapustsenka, Tatsiana
AU - Hosseini, Kamran
AU - Fischer-Friedrich, Elisabeth
AU - Corbeil, Denis
AU - Karbanová, Jana
AU - Taubenberger, Anna
AU - Dahncke, Björn
AU - Rauner, Martina
AU - Furesi, Giulia
AU - Perner, Sven
AU - Rost, Fabian
AU - Jessberger, Rolf
N1 - Publisher Copyright:
© 2024 Chang et al.
PY - 2024/8/1
Y1 - 2024/8/1
N2 - Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.
AB - Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.
UR - http://www.scopus.com/inward/record.url?scp=85193633830&partnerID=8YFLogxK
U2 - 10.26508/lsa.202302307
DO - 10.26508/lsa.202302307
M3 - Article
C2 - 38760173
AN - SCOPUS:85193633830
SN - 2575-1077
VL - 7
JO - Life Science Alliance
JF - Life Science Alliance
IS - 8
ER -