The Eye in Bone Marrow Transplantation: I. Clinical Study

Lawrence W. Hirst, Douglas A. Jabs, Peter J. Tutschka, George W. Santos, W. Richard Green

Research output: Contribution to journalArticlepeer-review

125 Scopus citations


A prospective study of 45 patients undergoing bone marrow transplantation included full ocular examination and pretransplant and posttransplant conjunctival biopsies. The major finding was the development of a severe keratoconjunctivitis sicca syndrome that developed in 20 of the 45 patients and closely correlated with the occurrence of acute graft-v-host disease (GVHD). An acute pseudomembranous conjunctivitis in the fulminant stage of acute GVHD developed in six patients. A further ten patients made up a retrospective assessment of bone marrow transplantation and confirmed these clinical findings.

Original languageEnglish
Pages (from-to)580-584
Number of pages5
JournalArchives of Ophthalmology
Issue number4
StatePublished - Apr 1983
Externally publishedYes


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