The EYA-SO/SIX complex in development and disease

Pin Xian Xu

doi:10.1007/s00467-012-2246-1

The EYA-SO/SIX complex in development and disease

Pin Xian Xu

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Eyes absent (EYA) and Sine oculis (SO/SIX) proteins function as transcriptional activation complexes and play essential roles in organogenesis during embryonic development in regulating cell proliferation and survival and coordination of particular differentiation programs. Mutations of the Eya and So/Six genes cause profound developmental defects in organisms as diverse as flies, frogs, fish, mice, and humans. EYA proteins also possess an intrinsic phosphatase activity, which is essential for normal development. Here, we review crucial roles of EYA and SO/SIX in development and disease in mice and humans.

Original language	English
Pages (from-to)	843-854
Number of pages	12
Journal	Pediatric Nephrology
Volume	28
Issue number	6
DOIs	https://doi.org/10.1007/s00467-012-2246-1
State	Published - Jun 2013

Keywords

Cell proliferation
Cell survival
Induction of ureteric bud
Phosphatase
Sensory placode
Specification of metanephric mesenchyme
Transcription factor
Ureter

Access to Document

10.1007/s00467-012-2246-1

Cite this

@article{158fc3258b7f49fda3df69f17a4faddf,

title = "The EYA-SO/SIX complex in development and disease",

abstract = "Eyes absent (EYA) and Sine oculis (SO/SIX) proteins function as transcriptional activation complexes and play essential roles in organogenesis during embryonic development in regulating cell proliferation and survival and coordination of particular differentiation programs. Mutations of the Eya and So/Six genes cause profound developmental defects in organisms as diverse as flies, frogs, fish, mice, and humans. EYA proteins also possess an intrinsic phosphatase activity, which is essential for normal development. Here, we review crucial roles of EYA and SO/SIX in development and disease in mice and humans.",

keywords = "Cell proliferation, Cell survival, Induction of ureteric bud, Phosphatase, Sensory placode, Specification of metanephric mesenchyme, Transcription factor, Ureter",

author = "Xu, {Pin Xian}",

note = "Funding Information: The author wishes to thank all of the past and present members of my lab for their many contributions and valuable discussions. Some of the work presented was supported by grants from the National Institutes of Health to P-X. X (NIH RO1 DC005824 and DK064640).",

year = "2013",

month = jun,

doi = "10.1007/s00467-012-2246-1",

language = "English",

volume = "28",

pages = "843--854",

journal = "Pediatric Nephrology",

issn = "0931-041X",

publisher = "Springer Verlag",

number = "6",

}

TY - JOUR

T1 - The EYA-SO/SIX complex in development and disease

AU - Xu, Pin Xian

N1 - Funding Information: The author wishes to thank all of the past and present members of my lab for their many contributions and valuable discussions. Some of the work presented was supported by grants from the National Institutes of Health to P-X. X (NIH RO1 DC005824 and DK064640).

PY - 2013/6

Y1 - 2013/6

N2 - Eyes absent (EYA) and Sine oculis (SO/SIX) proteins function as transcriptional activation complexes and play essential roles in organogenesis during embryonic development in regulating cell proliferation and survival and coordination of particular differentiation programs. Mutations of the Eya and So/Six genes cause profound developmental defects in organisms as diverse as flies, frogs, fish, mice, and humans. EYA proteins also possess an intrinsic phosphatase activity, which is essential for normal development. Here, we review crucial roles of EYA and SO/SIX in development and disease in mice and humans.

AB - Eyes absent (EYA) and Sine oculis (SO/SIX) proteins function as transcriptional activation complexes and play essential roles in organogenesis during embryonic development in regulating cell proliferation and survival and coordination of particular differentiation programs. Mutations of the Eya and So/Six genes cause profound developmental defects in organisms as diverse as flies, frogs, fish, mice, and humans. EYA proteins also possess an intrinsic phosphatase activity, which is essential for normal development. Here, we review crucial roles of EYA and SO/SIX in development and disease in mice and humans.

KW - Cell proliferation

KW - Cell survival

KW - Induction of ureteric bud

KW - Phosphatase

KW - Sensory placode

KW - Specification of metanephric mesenchyme

KW - Transcription factor

KW - Ureter

UR - http://www.scopus.com/inward/record.url?scp=84880573784&partnerID=8YFLogxK

U2 - 10.1007/s00467-012-2246-1

DO - 10.1007/s00467-012-2246-1

M3 - Review article

C2 - 22806561

AN - SCOPUS:84880573784

SN - 0931-041X

VL - 28

SP - 843

EP - 854

JO - Pediatric Nephrology

JF - Pediatric Nephrology

IS - 6

ER -

The EYA-SO/SIX complex in development and disease

Abstract

Keywords

Access to Document

Fingerprint

Cite this