The Extracellular Matrix and Cell–Biomaterial Interactions

Woojin M. Han, Young C. Jang, Andrés J. García

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations


The extracellular matrix (ECM) serves as a microenvironmental niche providing both biophysical and biochemical signals in which cells reside and function within the body. Therefore, understanding the composition, structure, and functions of the native ECM is essential to engineering biomaterials for maintaining and/or directing cellular function for biomedical applications. This chapter summarizes compositions, properties, and functions of the native ECM, and how these inform the understanding and engineering of cell–biomaterial interactions. The following concepts are covered:1. Definition, properties, and functions of the ECM2. Cell–biomaterial interactions.

Original languageEnglish
Title of host publicationBiomaterials Science
Subtitle of host publicationAn Introduction to Materials in Medicine
Number of pages15
ISBN (Electronic)9780128161371
ISBN (Print)9780128161388
StatePublished - 1 Jan 2020
Externally publishedYes


  • Cells
  • Extracellular matrix
  • Homeostasis
  • Organization
  • Stem cells
  • Tissue Constituents


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