The Expanding Armamentarium of Innovative Bioengineered Strategies to Augment Cardiovascular Repair and Regeneration

Stefan Elde, Hanjay Wang, Y. Joseph Woo

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Cardiovascular disease remains the leading cause of death worldwide. While clinical trials of cell therapy have demonstrated largely neutral results, recent investigations into the mechanisms of natural myocardial regeneration have demonstrated promising new intersections between molecular, cellular, tissue, biomaterial, and biomechanical engineering solutions. New insight into the crucial role of inflammation in natural regenerative processes may explain why previous efforts have yielded only modest degrees of regeneration. Furthermore, the new understanding of the interdependent relationship of inflammation and myocardial regeneration have catalyzed the emergence of promising new areas of investigation at the intersection of many fields.

Original languageEnglish
Article number674172
JournalFrontiers in Bioengineering and Biotechnology
Volume9
DOIs
StatePublished - 1 Jun 2021
Externally publishedYes

Keywords

  • bioengineering
  • cardiac regeneration
  • cell sheet and tissue engineering
  • heart regeneration
  • hydrogel
  • inflammation
  • myocardial regeneration
  • regeneration

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