The evoked potentials score improves the identification of benign MS without cognitive impairment

N. Margaritella; L. Mendozzi; F. Tronci; E. Colicino; M. Garegnani; R. Nemni; E. Gilardi; L. Pugnetti

doi:10.1111/ene.12071

The evoked potentials score improves the identification of benign MS without cognitive impairment

N. Margaritella, L. Mendozzi, F. Tronci, E. Colicino, M. Garegnani, R. Nemni, E. Gilardi, L. Pugnetti

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background and purpose: The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI. Methods: The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods. Results: Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05-0.005) compared to recent literature (39-46%). Conclusion: We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.

Original language	English
Pages (from-to)	1423-1425
Number of pages	3
Journal	European Journal of Neurology
Volume	20
Issue number	10
DOIs	https://doi.org/10.1111/ene.12071
State	Published - Oct 2013
Externally published	Yes

Keywords

Benign MS
Cognition
Evoked potentials
Evoked potentials score
Multiple sclerosis
Resampling methods

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10.1111/ene.12071

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title = "The evoked potentials score improves the identification of benign MS without cognitive impairment",

abstract = "Background and purpose: The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI. Methods: The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods. Results: Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05-0.005) compared to recent literature (39-46%). Conclusion: We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.",

keywords = "Benign MS, Cognition, Evoked potentials, Evoked potentials score, Multiple sclerosis, Resampling methods",

author = "N. Margaritella and L. Mendozzi and F. Tronci and E. Colicino and M. Garegnani and R. Nemni and E. Gilardi and L. Pugnetti",

year = "2013",

month = oct,

doi = "10.1111/ene.12071",

language = "English",

volume = "20",

pages = "1423--1425",

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TY - JOUR

T1 - The evoked potentials score improves the identification of benign MS without cognitive impairment

AU - Margaritella, N.

AU - Mendozzi, L.

AU - Tronci, F.

AU - Colicino, E.

AU - Garegnani, M.

AU - Nemni, R.

AU - Gilardi, E.

AU - Pugnetti, L.

PY - 2013/10

Y1 - 2013/10

N2 - Background and purpose: The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI. Methods: The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods. Results: Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05-0.005) compared to recent literature (39-46%). Conclusion: We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.

AB - Background and purpose: The presence of cognitive impairments (CI) among Benign MS (BMS) patients has challenged actual BMS criteria. We hypothesized that a low evoked potentials score (EP-score) at first neurological evaluation would help identify BMS patients without CI. Methods: The EP-score was retrospectively computed in 29 putative BMS patients who were then tested for CI during 2012. The difference in the prevalence of CI between low EP-score patients and the recent literature was assessed using resampling methods. Results: Among 23 low EP-score patients, only 3 (13%) had CI. This percentage was significantly reduced (P-values 0.05-0.005) compared to recent literature (39-46%). Conclusion: We conclude that a low EP-score at first neurological evaluation successfully helps to identify BMS patients without CI.

KW - Benign MS

KW - Cognition

KW - Evoked potentials

KW - Evoked potentials score

KW - Multiple sclerosis

KW - Resampling methods

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JO - European Journal of Neurology

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The evoked potentials score improves the identification of benign MS without cognitive impairment

Abstract

Keywords

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