The evaluation of tumor-infiltrating lymphocytes (TILS) in breast cancer: Recommendations by an International TILS Working Group 2014

R. Salgado; C. Denkert; S. Demaria; N. Sirtaine; F. Klauschen; G. Pruneri; S. Wienert; G. Van den Eynden; F. L. Baehner; F. Penault-Llorca; E. A. Perez; E. A. Thompson; W. F. Symmans; A. L. Richardson; J. Brock; C. Criscitiello; H. Bailey; M. Ignatiadis; G. Floris; J. Sparano; Z. Kos; T. Nielsen; D. L. Rimm; K. H. Allison; J. S. Reis-Filho; S. Loibl; C. Sotiriou; G. Viale; S. Badve; S. Adams; K. Willard-Gallo; Sherene Loi

doi:10.1093/annonc/mdu450

The evaluation of tumor-infiltrating lymphocytes (TILS) in breast cancer: Recommendations by an International TILS Working Group 2014

R. Salgado, C. Denkert, S. Demaria, N. Sirtaine, F. Klauschen, G. Pruneri, S. Wienert, G. Van den Eynden, F. L. Baehner, F. Penault-Llorca, E. A. Perez, E. A. Thompson, W. F. Symmans, A. L. Richardson, J. Brock, C. Criscitiello, H. Bailey, M. Ignatiadis, G. Floris, J. SparanoZ. Kos, T. Nielsen, D. L. Rimm, K. H. Allison, J. S. Reis-Filho, S. Loibl, C. Sotiriou, G. Viale, S. Badve, S. Adams, K. Willard-Gallo, Sherene Loi

Research output: Contribution to journal › Review article › peer-review

2254 Scopus citations

Abstract

Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes (TILs) in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists to facilitate their wider evaluation and consistent interpretation. The goal of this article is to promote the evaluation of TILs as a biomarker in research, clinical trial settings and day-to-day practice.

Original language	English
Pages (from-to)	259-271
Number of pages	13
Journal	Annals of Oncology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1093/annonc/mdu450
State	Published - 1 Feb 2015
Externally published	Yes

Keywords

Breast cancer (BC)
Clinical validity
Prediction
Prognosis
Tumor-infiltrating lymphocytes (TILs)

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Salgado, R., Denkert, C., Demaria, S., Sirtaine, N., Klauschen, F., Pruneri, G., Wienert, S., Van den Eynden, G., Baehner, F. L., Penault-Llorca, F., Perez, E. A., Thompson, E. A., Symmans, W. F., Richardson, A. L., Brock, J., Criscitiello, C., Bailey, H., Ignatiadis, M., Floris, G., ... Loi, S. (2015). The evaluation of tumor-infiltrating lymphocytes (TILS) in breast cancer: Recommendations by an International TILS Working Group 2014. Annals of Oncology, 26(2), 259-271. https://doi.org/10.1093/annonc/mdu450

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title = "The evaluation of tumor-infiltrating lymphocytes (TILS) in breast cancer: Recommendations by an International TILS Working Group 2014",

abstract = "Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes (TILs) in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists to facilitate their wider evaluation and consistent interpretation. The goal of this article is to promote the evaluation of TILs as a biomarker in research, clinical trial settings and day-to-day practice.",

keywords = "Breast cancer (BC), Clinical validity, Prediction, Prognosis, Tumor-infiltrating lymphocytes (TILs)",

author = "R. Salgado and C. Denkert and S. Demaria and N. Sirtaine and F. Klauschen and G. Pruneri and S. Wienert and {Van den Eynden}, G. and Baehner, {F. L.} and F. Penault-Llorca and Perez, {E. A.} and Thompson, {E. A.} and Symmans, {W. F.} and Richardson, {A. L.} and J. Brock and C. Criscitiello and H. Bailey and M. Ignatiadis and G. Floris and J. Sparano and Z. Kos and T. Nielsen and Rimm, {D. L.} and Allison, {K. H.} and Reis-Filho, {J. S.} and S. Loibl and C. Sotiriou and G. Viale and S. Badve and S. Adams and K. Willard-Gallo and Sherene Loi",

year = "2015",

month = feb,

day = "1",

doi = "10.1093/annonc/mdu450",

language = "English",

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Salgado, R, Denkert, C, Demaria, S, Sirtaine, N, Klauschen, F, Pruneri, G, Wienert, S, Van den Eynden, G, Baehner, FL, Penault-Llorca, F, Perez, EA, Thompson, EA, Symmans, WF, Richardson, AL, Brock, J, Criscitiello, C, Bailey, H, Ignatiadis, M, Floris, G, Sparano, J, Kos, Z, Nielsen, T, Rimm, DL, Allison, KH, Reis-Filho, JS, Loibl, S, Sotiriou, C, Viale, G, Badve, S, Adams, S, Willard-Gallo, K & Loi, S 2015, 'The evaluation of tumor-infiltrating lymphocytes (TILS) in breast cancer: Recommendations by an International TILS Working Group 2014', Annals of Oncology, vol. 26, no. 2, pp. 259-271. https://doi.org/10.1093/annonc/mdu450

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AU - Denkert, C.

AU - Demaria, S.

AU - Sirtaine, N.

AU - Klauschen, F.

AU - Pruneri, G.

AU - Wienert, S.

AU - Van den Eynden, G.

AU - Baehner, F. L.

AU - Penault-Llorca, F.

AU - Perez, E. A.

AU - Thompson, E. A.

AU - Symmans, W. F.

AU - Richardson, A. L.

AU - Brock, J.

AU - Criscitiello, C.

AU - Bailey, H.

AU - Ignatiadis, M.

AU - Floris, G.

AU - Sparano, J.

AU - Kos, Z.

AU - Nielsen, T.

AU - Rimm, D. L.

AU - Allison, K. H.

AU - Reis-Filho, J. S.

AU - Loibl, S.

AU - Sotiriou, C.

AU - Viale, G.

AU - Badve, S.

AU - Adams, S.

AU - Willard-Gallo, K.

AU - Loi, Sherene

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes (TILs) in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists to facilitate their wider evaluation and consistent interpretation. The goal of this article is to promote the evaluation of TILs as a biomarker in research, clinical trial settings and day-to-day practice.

AB - Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes (TILs) in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists to facilitate their wider evaluation and consistent interpretation. The goal of this article is to promote the evaluation of TILs as a biomarker in research, clinical trial settings and day-to-day practice.

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KW - Clinical validity

KW - Prediction

KW - Prognosis

KW - Tumor-infiltrating lymphocytes (TILs)

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SN - 0923-7534

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SP - 259

EP - 271

JO - Annals of Oncology

JF - Annals of Oncology

IS - 2

ER -

The evaluation of tumor-infiltrating lymphocytes (TILS) in breast cancer: Recommendations by an International TILS Working Group 2014

Abstract

Keywords

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