TY - JOUR
T1 - The Epstein Barr virus (EBV)
T2 - evidence for EBV strains
AU - Menezes, J.
AU - Leibold, W.
AU - Klein, G.
PY - 1975
Y1 - 1975
N2 - Biological criteria have been used in the past for defining strains, variants and mutants of several viruses, including herpes viruses. EBV has not been studied from this point of view, however. The present paper describes the biological evidence for the existance of at least 2 EBV strains. Results of experiments with these strains: the prototype human umbilical cord blood lymphocyte (CBL) transforming (B95-8) and the nontransforming (P3HR-1) EBV strains (from a Burkitt lymphoma) imply that lymphocyte transformation and EBV determined nuclear antigen (EBNA) induction in CBL on the one hand, and early antigen (EA) induction and growth inhibition of Raji cells on the other, are mutually exclusive EBV functions. The inability of P3HR-1 EBV to induce EBNA or EA in CBL or adult peripheral lymphomas (APL) may be due to the fact that it may require its target cell to be in a permanent blastoid state, like BJA-B or Raji, for the induction of these antigens. Although EA was not detected during the first few days in lymphocytes infected with B95-8 EBV, cells of some lymphoblastoid cell lines (LCL) obtained after lymphocyte transformation by this virus did produce EA, virus capsid antigen (VCA) and transforming particles.
AB - Biological criteria have been used in the past for defining strains, variants and mutants of several viruses, including herpes viruses. EBV has not been studied from this point of view, however. The present paper describes the biological evidence for the existance of at least 2 EBV strains. Results of experiments with these strains: the prototype human umbilical cord blood lymphocyte (CBL) transforming (B95-8) and the nontransforming (P3HR-1) EBV strains (from a Burkitt lymphoma) imply that lymphocyte transformation and EBV determined nuclear antigen (EBNA) induction in CBL on the one hand, and early antigen (EA) induction and growth inhibition of Raji cells on the other, are mutually exclusive EBV functions. The inability of P3HR-1 EBV to induce EBNA or EA in CBL or adult peripheral lymphomas (APL) may be due to the fact that it may require its target cell to be in a permanent blastoid state, like BJA-B or Raji, for the induction of these antigens. Although EA was not detected during the first few days in lymphocytes infected with B95-8 EBV, cells of some lymphoblastoid cell lines (LCL) obtained after lymphocyte transformation by this virus did produce EA, virus capsid antigen (VCA) and transforming particles.
UR - http://www.scopus.com/inward/record.url?scp=0016679650&partnerID=8YFLogxK
M3 - Article
C2 - 190135
AN - SCOPUS:0016679650
SN - 0300-5038
VL - No.11 I
SP - 323
EP - 330
JO - IARC scientific publications
JF - IARC scientific publications
ER -