Abstract

Drug-induced alterations in gene expression throughout the reward circuitry of the brain are likely components of the persistence of the drug-addicted state. Recent studies examining the molecular mechanisms controlling drug-induced transcriptional, behavioral, and synaptic plasticity have indicated a direct role for chromatin remodeling in the regulation and stability of drug-mediated neuronal gene programs, and the subsequent promulgation of addictive behaviors. In this review, we discuss recent advances in our understanding of chromatin phenomena-or epigenetics, by one definition-that contribute to drug addiction, with the hope that such mechanistic insights may aid in the development of novel therapeutics for future treatments of addiction.

Original languageEnglish
Pages (from-to)99-113
Number of pages15
JournalAnnals of the New York Academy of Sciences
Volume1216
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Chromatin
  • Drug addiction
  • Histone
  • Histone deacetylase (HDAC)
  • Histone methyltransferase (HMT)
  • Plasticity

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