The emerging roles of WBP2 oncogene in human cancers

Hossein Tabatabaeian; Angad Rao; Alisha Ramos; Tinghine Chu; Marius Sudol; Yoon Pin Lim

doi:10.1038/s41388-020-1318-0

The emerging roles of WBP2 oncogene in human cancers

Hossein Tabatabaeian
, Angad Rao
, Alisha Ramos
, Tinghine Chu
, Marius Sudol
, Yoon Pin Lim

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI₃K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.

Original language	English
Pages (from-to)	4621-4635
Number of pages	15
Journal	Oncogene
Volume	39
Issue number	24
DOIs	https://doi.org/10.1038/s41388-020-1318-0
State	Published - 11 Jun 2020

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title = "The emerging roles of WBP2 oncogene in human cancers",

abstract = "WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI3K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.",

author = "Hossein Tabatabaeian and Angad Rao and Alisha Ramos and Tinghine Chu and Marius Sudol and Lim, \{Yoon Pin\}",

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T1 - The emerging roles of WBP2 oncogene in human cancers

AU - Tabatabaeian, Hossein

AU - Rao, Angad

AU - Ramos, Alisha

AU - Chu, Tinghine

AU - Sudol, Marius

AU - Lim, Yoon Pin

PY - 2020/6/11

Y1 - 2020/6/11

N2 - WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI3K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.

AB - WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI3K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.

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VL - 39

SP - 4621

EP - 4635

JO - Oncogene

JF - Oncogene

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ER -

The emerging roles of WBP2 oncogene in human cancers

Abstract

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