The emerging roles of WBP2 oncogene in human cancers

Hossein Tabatabaeian, Angad Rao, Alisha Ramos, Tinghine Chu, Marius Sudol, Yoon Pin Lim

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI3K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.

Original languageEnglish
Pages (from-to)4621-4635
Number of pages15
JournalOncogene
Volume39
Issue number24
DOIs
StatePublished - 11 Jun 2020

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