TY - JOUR
T1 - The emerging roles of WBP2 oncogene in human cancers
AU - Tabatabaeian, Hossein
AU - Rao, Angad
AU - Ramos, Alisha
AU - Chu, Tinghine
AU - Sudol, Marius
AU - Lim, Yoon Pin
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/6/11
Y1 - 2020/6/11
N2 - WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI3K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.
AB - WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI3K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.
UR - http://www.scopus.com/inward/record.url?scp=85084489045&partnerID=8YFLogxK
U2 - 10.1038/s41388-020-1318-0
DO - 10.1038/s41388-020-1318-0
M3 - Review article
C2 - 32393834
AN - SCOPUS:85084489045
SN - 0950-9232
VL - 39
SP - 4621
EP - 4635
JO - Oncogene
JF - Oncogene
IS - 24
ER -