The emerging association between COVID-19 and acute stroke

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Prior to COVID-19, only two human-tropic coronaviruses resulted in epidemics and cerebrovascular disease was rarely reported. Evidence now suggests that 1–6% of hospitalized COVID-19 patients develop stroke. According to some reports, stroke risk is more than sevenfold greater in patients with COVID-19 than influenza. Concerningly, outcomes of COVID-19-related stroke are often worse than in stroke patients without COVID-19 from the same cohorts. In this review, we highlight the emerging association between COVID-19 and stroke and discuss putative pathogenetic mechanisms. Etiology of stroke in COVID-19 patients is likely multifactorial, related to coagulopathy, inflammation, platelet activation, and alterations to the vascular endothelium. Significant work remains to be done to better understand the pathogenesis of COVID-19-related stroke and for designing optimal primary and secondary prevention strategies.

Original languageEnglish
Pages (from-to)527-537
Number of pages11
JournalTrends in Neurosciences
Issue number7
StatePublished - Jul 2021


  • SARS-COV-2
  • cerebrovascular disease
  • coronavirus
  • pandemic
  • thrombectomy
  • thrombolysis
  • thrombosis


Dive into the research topics of 'The emerging association between COVID-19 and acute stroke'. Together they form a unique fingerprint.

Cite this