The effects of sodium nitroprusside on blood flow and oxygen delivery to the organs of the hypoxemic newborn lamb

Robert Mirro, J. Ross Milley, Ian R. Holzman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Vasodilators are used in newborns under conditions where hypoxia may be prominent. To study the effects of vasodilator therapy on organ oxygen delivery we measured blood flow (using radioactive microspheres) and arterial oxygen content in six chronically catheterized newborn lambs. Cardiac output and its distribution were measured during normoxia, hypoxia (10% O2 and 5% CO2), and hypoxia with a nitroprusside infusion. Hypoxia decreased oxygen content but did not change heart rate, mean blood pressure, or cardiac output. When nitroprusside was infused during hypoxemia, oxygen content and heart rate were not affected, but mean arterial blood pressure fell (39% decrease). During hypoxemia, blood flow increased to the heart, brain, and carcass but decreased to the gastrointestinal tract. When nitroprusside was infused during hypoxemia, blood flow decreased to the heart, brain, kidneys, and carcass. Oxygen delivery (arterial O2 content × blood flow) decreased to the brain as well as to kidneys, stomach, and carcass when nitroprusside was given to the hypoxemic lamb.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalPediatric Research
Volume19
Issue number1
DOIs
StatePublished - Jan 1985
Externally publishedYes

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