The effects of PM2.5 and its components from indoor and outdoor sources on cough and wheeze symptoms in asthmatic children

Rima Habre; Erin Moshier; William Castro; Amit Nath; Avi Grunin; Annette Rohr; James Godbold; Neil Schachter; Meyer Kattan; Brent Coull; Petros Koutrakis

doi:10.1038/jes.2014.21

The effects of PM_2.5 and its components from indoor and outdoor sources on cough and wheeze symptoms in asthmatic children

Rima Habre, Erin Moshier, William Castro, Amit Nath, Avi Grunin, Annette Rohr, James Godbold, Neil Schachter, Meyer Kattan, Brent Coull, Petros Koutrakis

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Particulate matter with aerodynamic diameter <2.5 μm (PM _2.5) is associated with asthma exacerbation. In the Children's Air Pollution Asthma Study, we investigated the longitudinal association of PM _2.5 and its components from indoor and outdoor sources with cough and wheeze symptoms in 36 asthmatic children. The sulfur tracer method was used to estimate infiltration factors. Mixed proportional odds models for an ordinal response were used to relate daily cough and wheeze scores to PM_2.5 exposures. The odds ratio associated with being above a given symptom score for a SD increase in PM_2.5 from indoor sources (PM IS) was 1.24 (95% confidence interval: 0.92-1.68) for cough and 1.63 (1.11-2.39) for wheeze. Ozone was associated with wheeze (1.82, 1.19-2.80), and cough was associated with indoor PM_2.5 components from outdoor sources (denoted with subscript "OS") bromine (Br_OS: 1.32, 1.05-1.67), chlorine (Cl _OS: 1.27, 1.02-1.59) and pyrolyzed organic carbon (OP_OS: 1.49, 1.12-1.99). The highest effects were seen in the winter for cough with sulfur (S_OS: 2.28, 1.01-5.16) and wheeze with organic carbon fraction 2 (OC2_OS: 7.46, 1.19-46.60). Our results indicate that exposure to components originating from outdoor sources of photochemistry, diesel and fuel oil combustion is associated with symptom's exacerbation, especially in the winter. PM_2.5 mass of indoor origin was more strongly associated with wheeze than with cough.

Original language	English
Pages (from-to)	380-387
Number of pages	8
Journal	Journal of Exposure Science and Environmental Epidemiology
Volume	24
Issue number	4
DOIs	https://doi.org/10.1038/jes.2014.21
State	Published - 2014

Keywords

Asthma
Components
Infiltration
Ozone
Particulate matter
Symptoms

Access to Document

10.1038/jes.2014.21

Cite this

Habre, R., Moshier, E., Castro, W., Nath, A., Grunin, A., Rohr, A., Godbold, J., Schachter, N., Kattan, M., Coull, B., & Koutrakis, P. (2014). The effects of PM_2.5 and its components from indoor and outdoor sources on cough and wheeze symptoms in asthmatic children. Journal of Exposure Science and Environmental Epidemiology, 24(4), 380-387. https://doi.org/10.1038/jes.2014.21

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title = "The effects of PM2.5 and its components from indoor and outdoor sources on cough and wheeze symptoms in asthmatic children",

abstract = "Particulate matter with aerodynamic diameter <2.5 μm (PM 2.5) is associated with asthma exacerbation. In the Children's Air Pollution Asthma Study, we investigated the longitudinal association of PM 2.5 and its components from indoor and outdoor sources with cough and wheeze symptoms in 36 asthmatic children. The sulfur tracer method was used to estimate infiltration factors. Mixed proportional odds models for an ordinal response were used to relate daily cough and wheeze scores to PM2.5 exposures. The odds ratio associated with being above a given symptom score for a SD increase in PM2.5 from indoor sources (PM IS) was 1.24 (95% confidence interval: 0.92-1.68) for cough and 1.63 (1.11-2.39) for wheeze. Ozone was associated with wheeze (1.82, 1.19-2.80), and cough was associated with indoor PM2.5 components from outdoor sources (denoted with subscript {"}OS{"}) bromine (BrOS: 1.32, 1.05-1.67), chlorine (Cl OS: 1.27, 1.02-1.59) and pyrolyzed organic carbon (OPOS: 1.49, 1.12-1.99). The highest effects were seen in the winter for cough with sulfur (SOS: 2.28, 1.01-5.16) and wheeze with organic carbon fraction 2 (OC2OS: 7.46, 1.19-46.60). Our results indicate that exposure to components originating from outdoor sources of photochemistry, diesel and fuel oil combustion is associated with symptom's exacerbation, especially in the winter. PM2.5 mass of indoor origin was more strongly associated with wheeze than with cough.",

keywords = "Asthma, Components, Infiltration, Ozone, Particulate matter, Symptoms",

author = "Rima Habre and Erin Moshier and William Castro and Amit Nath and Avi Grunin and Annette Rohr and James Godbold and Neil Schachter and Meyer Kattan and Brent Coull and Petros Koutrakis",

note = "Funding Information: This study was supported by the Electric Power Research Institute (EP-P15909/C7932). R Habre was supported by the Harvard School of Public Health Dean{\textquoteright}s Scholarship. We thank Tom Gentile, George O{\textquoteright}Connor and Lance Wallace, members of the CAPAS study scientific advisory committee, for their guidance in all phases of the study. Stephen Ferguson and Mike Wolfson are also acknowledged for designing the air sampling monitors and conducting laboratory analyses. We also thank all the individuals who participated in this study.",

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doi = "10.1038/jes.2014.21",

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Habre, R, Moshier, E, Castro, W, Nath, A, Grunin, A, Rohr, A, Godbold, J, Schachter, N, Kattan, M, Coull, B & Koutrakis, P 2014, 'The effects of PM_2.5 and its components from indoor and outdoor sources on cough and wheeze symptoms in asthmatic children', Journal of Exposure Science and Environmental Epidemiology, vol. 24, no. 4, pp. 380-387. https://doi.org/10.1038/jes.2014.21

TY - JOUR

T1 - The effects of PM2.5 and its components from indoor and outdoor sources on cough and wheeze symptoms in asthmatic children

AU - Habre, Rima

AU - Moshier, Erin

AU - Castro, William

AU - Nath, Amit

AU - Grunin, Avi

AU - Rohr, Annette

AU - Godbold, James

AU - Schachter, Neil

AU - Kattan, Meyer

AU - Coull, Brent

AU - Koutrakis, Petros

N1 - Funding Information: This study was supported by the Electric Power Research Institute (EP-P15909/C7932). R Habre was supported by the Harvard School of Public Health Dean’s Scholarship. We thank Tom Gentile, George O’Connor and Lance Wallace, members of the CAPAS study scientific advisory committee, for their guidance in all phases of the study. Stephen Ferguson and Mike Wolfson are also acknowledged for designing the air sampling monitors and conducting laboratory analyses. We also thank all the individuals who participated in this study.

PY - 2014

Y1 - 2014

N2 - Particulate matter with aerodynamic diameter <2.5 μm (PM 2.5) is associated with asthma exacerbation. In the Children's Air Pollution Asthma Study, we investigated the longitudinal association of PM 2.5 and its components from indoor and outdoor sources with cough and wheeze symptoms in 36 asthmatic children. The sulfur tracer method was used to estimate infiltration factors. Mixed proportional odds models for an ordinal response were used to relate daily cough and wheeze scores to PM2.5 exposures. The odds ratio associated with being above a given symptom score for a SD increase in PM2.5 from indoor sources (PM IS) was 1.24 (95% confidence interval: 0.92-1.68) for cough and 1.63 (1.11-2.39) for wheeze. Ozone was associated with wheeze (1.82, 1.19-2.80), and cough was associated with indoor PM2.5 components from outdoor sources (denoted with subscript "OS") bromine (BrOS: 1.32, 1.05-1.67), chlorine (Cl OS: 1.27, 1.02-1.59) and pyrolyzed organic carbon (OPOS: 1.49, 1.12-1.99). The highest effects were seen in the winter for cough with sulfur (SOS: 2.28, 1.01-5.16) and wheeze with organic carbon fraction 2 (OC2OS: 7.46, 1.19-46.60). Our results indicate that exposure to components originating from outdoor sources of photochemistry, diesel and fuel oil combustion is associated with symptom's exacerbation, especially in the winter. PM2.5 mass of indoor origin was more strongly associated with wheeze than with cough.

AB - Particulate matter with aerodynamic diameter <2.5 μm (PM 2.5) is associated with asthma exacerbation. In the Children's Air Pollution Asthma Study, we investigated the longitudinal association of PM 2.5 and its components from indoor and outdoor sources with cough and wheeze symptoms in 36 asthmatic children. The sulfur tracer method was used to estimate infiltration factors. Mixed proportional odds models for an ordinal response were used to relate daily cough and wheeze scores to PM2.5 exposures. The odds ratio associated with being above a given symptom score for a SD increase in PM2.5 from indoor sources (PM IS) was 1.24 (95% confidence interval: 0.92-1.68) for cough and 1.63 (1.11-2.39) for wheeze. Ozone was associated with wheeze (1.82, 1.19-2.80), and cough was associated with indoor PM2.5 components from outdoor sources (denoted with subscript "OS") bromine (BrOS: 1.32, 1.05-1.67), chlorine (Cl OS: 1.27, 1.02-1.59) and pyrolyzed organic carbon (OPOS: 1.49, 1.12-1.99). The highest effects were seen in the winter for cough with sulfur (SOS: 2.28, 1.01-5.16) and wheeze with organic carbon fraction 2 (OC2OS: 7.46, 1.19-46.60). Our results indicate that exposure to components originating from outdoor sources of photochemistry, diesel and fuel oil combustion is associated with symptom's exacerbation, especially in the winter. PM2.5 mass of indoor origin was more strongly associated with wheeze than with cough.

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