The effects of foetuin on lymphocytes: Lymphocyte stimulating property

C. C.S. Hsu, W. I. Waithe, P. Hathaway, K. Hirschhorn

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The effect of an isolated calf foetal protein, foetuin, on lymphocyte cultures in vitro was studied using bovine serum albumin and lyophilized calf serum as controls. Four different lots of foetuin were found to induce blast transformation and protein and DNA synthesis of human peripheral blood lymphocytes. The peak responses were reached after 5 to 6 days of culture. Lymphocytes from bovine mesenteric lymph nodes were also stimulated after 6 days of culture. The lymphocyte stimulating property associated with foetuin was stable to freeze thawing but destroyed by heating at 80±C for 60 min. HeLa cell growth promoting factor known to be present in ammonium sulphate precipitated foetuin preparations was excluded from responsibility for the mitogenic effect observed.

Original languageEnglish
Pages (from-to)427-434
Number of pages8
JournalClinical and Experimental Immunology
Issue number3
StatePublished - 1973
Externally publishedYes


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