The effects of diet and physical activity on plasma homovanillic acid in normal human subjects

Kenneth S. Kendler, Richard C. Mohs, Kenneth L. Davis

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

This study examines the effect of diet and moderate physical activity on plasma levels of the dopamine metabolite homovanillic acid (HVA) in healthy young males. At weekly intervals, subjects were fed four isocaloric meals: polycose (pure carbohydrate), sustecal, low monoamine, and high monoamine. Moderate physical activity consisted of 30 minutes of exercise on a bicycle ergometer. The effect of diet on plasma HVA (pHVA) was highly significant. Compared to the polycose meal, the high monoamine meal significantly increased pHVA. Moderate physical activity also significantly increased pHVA. Future clinical studies using pHVA in man as an index of brain dopamine function should control for the effects of both diet and physical activity.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalPsychiatry Research
Volume8
Issue number3
DOIs
StatePublished - Mar 1983
Externally publishedYes

Keywords

  • Homovanillic acid
  • diet
  • physical activity

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