The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans

Dennis S. Charney; Matthew P. Galloway; George R. Heninger

doi:10.1016/0024-3205(84)90132-2

The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans

Dennis S. Charney
, Matthew P. Galloway
, George R. Heninger

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

The effects of oral administration of caffeine (10 mg/kg) on plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) levels, behavioral ratings, blood pressure, and autonomic symptoms was determined in eleven healthy subjects. Caffeine produced robust increases in subject rated anxiety and nervousness and small elevations in blood pressure and a decrease in heart rate. Caffeine did not alter plasma MHPG in a consistent fashion and there was no correlation between changes in plasma MHPG and changes in anxiety or other ratings. Caffeine may produce symptoms of anxiety-nervousness without increasing central norepinephrine turnover.

Original language	English
Pages (from-to)	135-144
Number of pages	10
Journal	Life Sciences
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(84)90132-2
State	Published - 9 Jul 1984
Externally published	Yes

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@article{a96d6601715f447989208c495b156062,

title = "The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans",

abstract = "The effects of oral administration of caffeine (10 mg/kg) on plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) levels, behavioral ratings, blood pressure, and autonomic symptoms was determined in eleven healthy subjects. Caffeine produced robust increases in subject rated anxiety and nervousness and small elevations in blood pressure and a decrease in heart rate. Caffeine did not alter plasma MHPG in a consistent fashion and there was no correlation between changes in plasma MHPG and changes in anxiety or other ratings. Caffeine may produce symptoms of anxiety-nervousness without increasing central norepinephrine turnover.",

author = "Charney, \{Dennis S.\} and Galloway, \{Matthew P.\} and Heninger, \{George R.\}",

note = "Funding Information: This study was supported in part by the State of Connecticut and USPHS Grants \textasciitilde{}-38007, MH-25642, MH-14276, MH-30929, and MH-36229. Peter Jatlow, M.D. performed the plasma caffeine assays. K. Hafstad, S. Capelli, L. Quadrino, D. Franklin and the nurses of the Clinical Research Unit provided expert nursing and technical assistance. We also acknowledge the expert laboratory assistance of Dora Wenger, Suzanne Strom, and Jan Abele. Evelyn Testa typed the manuscript.",

year = "1984",

month = jul,

day = "9",

doi = "10.1016/0024-3205(84)90132-2",

language = "English",

volume = "35",

pages = "135--144",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans

AU - Charney, Dennis S.

AU - Galloway, Matthew P.

AU - Heninger, George R.

N1 - Funding Information: This study was supported in part by the State of Connecticut and USPHS Grants ~-38007, MH-25642, MH-14276, MH-30929, and MH-36229. Peter Jatlow, M.D. performed the plasma caffeine assays. K. Hafstad, S. Capelli, L. Quadrino, D. Franklin and the nurses of the Clinical Research Unit provided expert nursing and technical assistance. We also acknowledge the expert laboratory assistance of Dora Wenger, Suzanne Strom, and Jan Abele. Evelyn Testa typed the manuscript.

PY - 1984/7/9

Y1 - 1984/7/9

N2 - The effects of oral administration of caffeine (10 mg/kg) on plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) levels, behavioral ratings, blood pressure, and autonomic symptoms was determined in eleven healthy subjects. Caffeine produced robust increases in subject rated anxiety and nervousness and small elevations in blood pressure and a decrease in heart rate. Caffeine did not alter plasma MHPG in a consistent fashion and there was no correlation between changes in plasma MHPG and changes in anxiety or other ratings. Caffeine may produce symptoms of anxiety-nervousness without increasing central norepinephrine turnover.

AB - The effects of oral administration of caffeine (10 mg/kg) on plasma free 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) levels, behavioral ratings, blood pressure, and autonomic symptoms was determined in eleven healthy subjects. Caffeine produced robust increases in subject rated anxiety and nervousness and small elevations in blood pressure and a decrease in heart rate. Caffeine did not alter plasma MHPG in a consistent fashion and there was no correlation between changes in plasma MHPG and changes in anxiety or other ratings. Caffeine may produce symptoms of anxiety-nervousness without increasing central norepinephrine turnover.

UR - https://www.scopus.com/pages/publications/0021276850

U2 - 10.1016/0024-3205(84)90132-2

DO - 10.1016/0024-3205(84)90132-2

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C2 - 6738307

AN - SCOPUS:0021276850

SN - 0024-3205

VL - 35

SP - 135

EP - 144

JO - Life Sciences

JF - Life Sciences

IS - 2

ER -

The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans

Abstract

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