Abstract
The cannabis plant contains around 60 aromatic hydrocarbon compounds known as cannabinoids, including delta-9-tetrahydocannabinol (THC), which is primarily psychotropic; cannabidiol (CBD), efficacious in inflammation, motility and analgesia; and cannabigerol, the effect of which is still to be determined. Cannabis has been used to ameliorate a variety of gastrointestinal disorders including abdominal pain, nausea, vomiting, diarrhea/constipation, manifestations of inflammation within the gastrointestinal system, and dysmotility. This chapter reviews the endocannabinoid system as it relates to the gastrointestinal tract and associated organs, followed by specific indications based on disease entities. Appreciating that the reliability and reproducibility of clinical trials of medical cannabis on the gastrointestinal system are poor due to the lack of standardization of cannabinoid products, there are promising results that show potential benefits in a select group of patients.
Original language | English |
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Title of host publication | Cannabis Use in Medicine |
Subtitle of host publication | A Concise Handbook |
Publisher | Springer International Publishing |
Pages | 75-83 |
Number of pages | 9 |
ISBN (Electronic) | 9783031127229 |
ISBN (Print) | 9783031127212 |
DOIs | |
State | Published - 1 Jan 2022 |
Externally published | Yes |
Keywords
- Cannabis
- Gastrointestinal tract
- Inflammatory bowel disease
- Irritable bowel syndrome
- Pancreas